磷酸化細胞分裂周期蛋白16抗體（）

英文名稱：Anti-phospho-APC6/CDC16（Thr580）                                 濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應： Human, 

產品類型: 一抗  

性    狀:   Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產品介紹 ：Cell cycle events are regulated by the sequential activation and deactivation of cyclin dependent kinases （Cdks） and by the proteolysis of cyclins. The cell division cycle （Cdc） genes are required at various points in the cell cycle. Cdc25A, Cdc25B and Cdc25C protein tyrosine phosphatases function as mitotic activators by dephosphorylating Cdc2 p34 on regulatory tyrosine residues. Cdc6 is the human homolog of Saccharomyces cerevisiae Cdc6, which is involved in the initiation of DNA replication. Cdc37 appears to facilitate Cdk4/cyclin D1 complex formation and has been shown to form a stable complex with Hsp90. Cdc34, Cdc27 and Cdc16 function as ubiquitin-conjugating enzymes. Cdc34 is thought to be the structural and functional homolog of Saccharomyces cerevisiae Cdc34, which is essential for the G1 to S phase transition. Cdc16 and Cdc27 are components of the APC （anaphase-promoting complex） which ubiquitinates cyclin B, resulting in cyclin B/Cdk complex degradation.

Function : Component of the anaphase promoting complex/cyclosome （APC/C）, a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. 
Subcellular Location : Cytoplasm > cytoskeleton > centrosome. Cytoplasm > cytoskeleton > spindle. Colocalizes with CDC27 to the centrosome at all stages of the cell cycle and to the mitotic spindle.
Post-translational modifications : Phosphorylated. Phosphorylation on Ser-560 occurs specifically during mitosis.
Similarity : Belongs to the APC6/CDC16 family.
Contains 7 TPR repeats. 

公司對外提供生物技術外包服務：卡邁舒（上海）生物科技專業經營一抗二抗,單克隆多克隆抗體,指標上千萬種,質量好,價格實惠,售后問題負責到底,

單克隆抗體定制服務，多克隆抗體定制，單克隆抗體純化   ，多克隆抗體純化  ，

抗體HRP標記  ，抗原HRP標記  ，抗體膠體金標記，抗體FITC標記，小鼠單抗Ig類/亞類鑒定，獸用細胞水平檢測（比如干擾素等），多肽半抗原的偶聯，

親和層析柱制備 （客戶提供抗原抗體）