腺瘤性結腸息肉病蛋白2抗體（）

英文名稱：  Anti-APCL/APC2                                  濃度： 1mg/1ml 

抗體來源：Rabbit

克隆類型：polyclonal          

 交叉反應： Human, Mouse, Rat, Dog, Pig, Horse, 

產品類型: 一抗  

性    狀:   Lyophilized or Liquid 

保存條件： Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產品介紹 ：The adenomatous polyposis syndromes, familial adenomatous polyposis （FAP） and Gardner’s syndrome （GS）, are characterized by numerous adenomatous polyps throughout the entire colon. These polyps invariably progress to colon cancer in addition to other extracolonic manifestations. The cloning of the APC gene revealed a ubiquitously expressed protein, 2843 amino acids in length, which is frequently mutated in patients suffering from FAP and GS. APC has been found to be associated with structural components of intracellular junctions. b-catenin and g-catenin （also called plakoglobin） are involved in the regulation of cellular adhesion. APC and E cadherin compete for binding to specific internal regions of both b- and g-catenin. Interactions between cytoskeleton and the APC, E cadherin, b/g catenin complex are mediated by a-catenin. 

Function : APC2 might function in the Wnt signaling pathway through it's ability to promote the rapid degradation of beta-catenin. It also functions as a tumour suppressor.
Subunit : Interacts with PSRC1 （By similarity）. Interacts with APC, CTNNB1, MAPRE1, MAPRE3, TP53BP2 and possibly with AXIN2. 
Subcellular Location : Cell Membrane, Cytoplasmic and Golgi Apparatus
Tissue Specificity : Widely expressed （at protein level）. Specifically expressed in the CNS. 
Similarity : Belongs to the adenomatous polyposis coli （APC） family. 
Contains 6 ARM repeats. 
Database links : UniProtKB/Swiss-Prot: O95996.1

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單克隆抗體定制服務，多克隆抗體定制，單克隆抗體純化   ，多克隆抗體純化  ，

抗體HRP標記  ，抗原HRP標記  ，抗體膠體金標記，抗體FITC標記，小鼠單抗Ig類/亞類鑒定，獸用細胞水平檢測（比如干擾素等），多肽半抗原的偶聯，

親和層析柱制備 （客戶提供抗原抗體）