ABL2蛋白抗體價(jià)格現(xiàn)貨供應(yīng)，產(chǎn)品價(jià)格洽談，公司提供完整的，提供*的售前售后服務(wù)！
英文名稱 ABL2
中文名稱 ABL2蛋白抗體價(jià)格
別    名 Abelson murine leukemia viral oncogene homolog 2; Abelson related gene protein; Tyrosine kinase ARG; ABLL;ARG;Tyrosine protein kinase ABL2; v abl Abelson murine leukemia viral oncogene homolog 2; ABL2_HUMAN; Abelson tyrosine-protein kinase 2; Tyrosine-protein kinase ARG.
ABL2蛋白抗體價(jià)格
研究領(lǐng)域 腫瘤  細(xì)胞生物  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞凋亡  激酶和磷酸酶  
抗體來(lái)源 Rabbit
克隆類(lèi)型 Polyclonal
交叉反應(yīng) Human, Mouse, Rat, Dog, Pig, Horse, Rabbit, 
產(chǎn)品應(yīng)用 WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 120kDa
細(xì)胞定位 細(xì)胞漿 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ABL2
亞    型 IgG
純化方法 affinity purified by Protein A
儲(chǔ) 存 液 0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide

ABL2蛋白抗體價(jià)格咨詢及訂購(gòu)的方法：

1.可通過(guò)來(lái)電向我司銷(xiāo)售人員直接咨詢及訂購(gòu)；

2.可通過(guò)本網(wǎng)頁(yè)上的“交談”向我司在線銷(xiāo)售人員咨詢及訂購(gòu)；

3.可在本頁(yè)下方留言欄內(nèi)留言，我們會(huì)以zui快的速度您；

4.可通過(guò)郵件向我司在線銷(xiāo)售人員咨詢及訂購(gòu)。

ABL2蛋白抗體價(jià)格
產(chǎn)品介紹 background:
This gene encodes a member of the Abelson family of nonreceptor tyrosine protein kinases. The protein is highly similar to the c-abl oncogene 1 protein, including the tyrosine kinase, SH2 and SH3 domains, and it plays a role in cytoskeletal rearrangements through its C-terminal F-actin- and microtubule-binding sequences. This gene is expressed in both normal and tumor cells, and is involved in translocation with the ets variant 6 gene in leukemia. Multiple alternatively spliced transcript variants encoding different protein isoforms have been found for this gene. [provided by RefSeq, Nov 2009]

Function:
Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement); CTTN (involved in signaling); or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.

Subunit:
Interacts with PSMA7. Interacts with CTTN.

Subcellular Location:
Cytoplasm, cytoskeleton.

Tissue Specificity:
Widely expressed.

Post-translational modifications:
Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB.
Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation.

Similarity:
Belongs to the protein kinase superfamily. Tyr protein kinase family. ABL subfamily.
Contains 1 protein kinase domain.
Contains 1 SH2 domain.
Contains 1 SH3 domain.

Gene ID:
27

Database links:

Entrez Gene: 27 Human

Entrez Gene: 11352 Mouse

Entrez Gene: 304883 Rat

Omim: 164690 Human

SwissProt: P42684 Human

SwissProt: Q4JIM5 Mouse

Unigene: 159472 Human

Unigene: 329515 Mouse

Unigene: 69847 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
ABL-2屬Abelson（白血病病毒）家族的非受體*激酶，目前主要用于惡性腫瘤的研究。
廠家*鹽酸三乙胺/三乙胺鹽酸鹽/三乙基氯化銨/N,N'-二乙基乙胺鹽酸鹽/氯化四乙胺/對(duì)羥基苯基乙胺鹽酸鹽/干酪毒素鹽酸鹽/Triethylamine hydrochloride
廠家*N-乙基二異丙胺/N，N-二異丙基乙胺/二異丙基乙胺/二異丙基乙基胺/N,N-異丙基乙胺/DIPEA
DAPI染色液(10ug/ml)10ml細(xì)胞染色森貝伽
SDS-PAGE蛋白加樣緩沖液(6×)1ml蛋白電泳森貝伽
Rat factor B,BF ELISA KIT大鼠B因子(BF)ELISA試劑盒ELISA. 96T/48T
廠家*組蛋白H1（小牛胸腺）/Histones H1 from calf thymus
廠家*鹽酸*胺/*胺鹽酸鹽/*基氯化銨/鹽酸氨基*烷/N,N-二甲基甲胺鹽酸鹽/氯化*銨/Trimethylamine hydrochloride
DAPI染色液(10ug/ml)50ml細(xì)胞染色森貝伽
SDS-PAGE蛋白加樣緩沖液(6×)5×1ml蛋白電泳森貝伽
Rat Oncostatin-M,OSM ELISA KIT大鼠抑瘤素M(OSM)ELISA試劑盒ELISA. 96T/48T
廠家*粘蛋白/Mucin
廠家*三異辛胺/三異辛基胺/三(2-乙基已基)胺/Triisooctylamine
廠家**/1-β-D-呋喃核糖基-1H-1,2,4,-三氮唑-3-羧酰胺/1-β-D呋喃核糖-1,2,4-三氮唑-3-羥酰胺/*/*/三氨唑核苷/三唑核苷/Ribavirin
DAPI染色儲(chǔ)存液(1mg/ml)1ml細(xì)胞染色森貝伽
SDS-PAGE蛋白加樣緩沖液(6×)10ml蛋白電泳森貝伽
Rat placenta growth factor,PLGF ELISA KIT大鼠胎盤(pán)生長(zhǎng)因子(PLGF)ELISA試劑盒ELISA. 96T/48T
廠家*胃粘膜素/粘液素II/粘液素III/*/Mucin
廠家*六甲基磷酰三胺/六磷胺/三(二甲氨基)氧膦/磷酰三(二甲胺)/六甲基磷酰胺/六甲基磷酸三胺/六甲磷酰三胺/六偏磷酸銨/HMPT/HMPA
廠家*1,2,4,5-苯四甲酸酐/1,2,4,5-苯四甲羧酸二酐/1H,3H-苯并[1,2-C:4,5-C’]二呋喃-1,3,5,7-四酮/苯均四酸酐/1,2,4,5-均苯四甲酸二酐/均苯四甲酸二酐/均苯四甲酸酐/1,2,4,5-苯四酸酐/PMDA
Hoechst33258染色液10ml細(xì)胞染色森貝伽
PAGE不連續(xù)凝膠電極緩沖液(2×)100ml蛋白電泳森貝伽?