英文名稱 ZZZ3
中文名稱 鋅指蛋白ZZZ3抗體
別    名 ATAC component 1 homolog; ATAC1; DKFZp313N0119; DKFZp564I052; FLJ10362; Zinc finger ZZ domain containing 3; Zinc finger ZZ type containing 3; ZZ type zinc finger containing protein 3; ZZ-type zinc finger-containing protein 3; ZZZ 3; ZZZ3; ZZZ3_HUMAN.
說 明 書 0.2ml
研究領域 細胞生物  轉錄調節因子  表觀遺傳學
鋅指蛋白ZZZ3抗體抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Horse,
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 102kDa
細胞定位 細胞核
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human ZZZ3
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產品介紹 background:
ZZZ3 (ZZ-type zinc finger-containing protein 3) is a 903 amino acid protein that contains one HTH myb-type DNA-binding domain and one ZZ-type zinc finger. Phosphorylated upon DNA damage by ATM or ATR, ZZZ3 is a subunit of the ATAC complex, which is composed of GCN5, CRP2BP, ADA3, TADA2L, DR1, CCDC101, YEATS2, WDR5 and MBIP. The ATAC complex has histone acetyltransferase activity on histones H3 and H4. ZZZ3 is expressed as four isoforms produced by alternative splicing and is encoded by a gene mapping to human chromosome 1. Chromosome 1 is the largest human chromosome spanning about 260 million base pairs and making up 8% of the human genome. There are about 3,000 genes on chromosome 1, and considering the great number of genes there are also a large number of diseases associated with chromosome 1. Notably, the rare aging disease Hutchinson-Gilford progeria is associated with the LMNA gene which encodes lamin A. When defective, the LMNA gene product can build up in the nucleus and cause characteristic nuclear blebs. The mechanism of rapidly enhanced aging is unclear and is a topic of continuing exploration. Stickler syndrome, Parkinsons, Gaucher disease and Usher syndrome are also associated with chromosome 1.

Function:
Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4.

Subcellular Location:
Nucleus.

Post-translational modifications:
Phosphorylated upon DNA damage, probably by ATM or ATR.

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

南京森貝伽生物科技有限公司在抗體的純化方面我們采用親和層析技術，親和層析是一種吸附層析，一步親和層析就可達到超過99%的純度。在抗體的檢測方面我們執行嚴格的檢測標準，為您提供高品質抗體。我們的每一個抗體都經過嚴格檢測和穩定性測試，保證了結果的準確性、敏感性、特異性。