santacruz GSK-3 Inhibitor X
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GSK-3 Inhibitor X (CAS 740841-15-0)

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Synonym:	BIO-Acetoxime; 6-Bromoindirubin-3′-acetoxime, BIA
Application:	A selective GSK-3α/β inhibitor
CAS Number:	740841-15-0
Purity:	≥95%
Molecular Weight:	398.21
Molecular Formula:	C₁₈H₁₂BrN₃O₃
Refer to Certificate of Analysis for lot specific data (including water content).

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Product Name	Catalog #	Unit	Price	Qty	Add	Favorites
GSK-3 Inhibitor X	sc-221689	1 mg	$115		Add

Description

GSK-3 Inhibitor X is an acetoxime analog of BIO which acts as a selective GSK-3α/β inhibitor (IC₅₀ values are 0.01, 2.4, 4.3 and 63 μM for GSK-3α/β, CDK5/p25, CDK2/cyclin A and CDK1/cyclin B respectively). GSK-3 Inhibitor X induces Wnt signaling and inhibits CD8+ T cell effector differentiation.

Technical Information

Physical State:	Solid
Solubility:	Soluble in DMSO (10 mg/ml).
Storage:	Store at 4° C
Melting Point:	236.83 °C (Predicted)
Boiling Point:	551.87 °C (Predicted)
Density:	1.69 g/cm³ (Predicted)
Refractive Index:	n²⁰_D 1.74 (Predicted)
IC50:	GSK-3α/β: IC₅₀ = 10 nM; Cdk5/p25: IC₅₀ = 2.4 µM; Cdk2/A: IC₅₀ = 4.3 µM; Cdk1/B: IC₅₀ = 63 µM; Cdk4/D1: IC₅₀ = ≥10 µM; aryl hydrocarbon receptor: EC₅₀50 = ≥0.1 µM (yeast); aryl hydrocarbon receptor: EC₅₀50 = 0.16 µM (mammalian)
pK Values:	pK_a: 9.23 (Predicted)

Safety and Reference Information

PubChem CID:	6538818
MDL Number:	MFCD09037533
SMILES:	CC(=O)ONC1=C2C=CC=CC2=NC1=C3C4=C(C=C(C=C4)Br)NC3=O

For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.

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