產品名稱：Trichostatin A
貨號：sigma T1952
規格：200ul
Trichostatin A, Ready Made Solution
5 mM in DMSO （0.2 μm-filtered）, from Streptomyces sp.
別名: TSA [R-（E,E）]-7-[4-（Dimethylamino）phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide
性質：
Related Categories Antibiotic Ready Made Solutions, Antibiotics, Bioactive Small Molecules, Bioactive Small Molecules for Epigenetic Research, Cell Biology,
Cell Signaling and Neuroscience, DNA-RNA Transcription Regulators, Epigenetics, Gene Regulation and Expression, Histone Deacetylase Inhibitors, Hydroxamic Acid Inhibitors, Molecular Biology, Reagents, T, Tools for Gene Regulation Research
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biological source from Streptomyces sp. 
form DMSO solution 
concentration 5 mM in DMSO （0.2 μm-filtered） 
shipped in dry ice 
storage temp. −20°C 
說明
Biochem/physiol Actions
Trichostatin A （TSA） is a Streptomyces metabolite, which specifically inhibits mammalian histone deacetylase at a nanomolar concentration and causes accumulation of highly acetylated histone molecules in mammalian cells. For that reason, trichostatin A is a tool to study the consequences of histone acetylation in vivo.1 Trichostatin A induces cell differentiation, cell cycle arrest, reversal of transformed cells morphology, and apoptosis and is able to modulate transcription.2,3 TSA has been used to establish a new cloning technique, which increases the success rates for mouse cloning.4