???????:????????????MICROSTRUCTURED HYDROGELS????3D?????????????壨SMART sphero PLATES??MICROWELLS FOR SPHEROID ASSEMBLY??,??????????????壨SMART[contractility] PLATES??ASSEMBLY OF RING-SPHAPED ORGANOIDS?????:????4dcell????:MICROSTRUCTURED HYDROGELS???:????????:???????綽:

4DCELL?????

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SMART[sphero] PLATES

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SMART[contractility] PLATES

A3d????????????????,?????????????SSEMBLY OF RING-SPHAPED ORGANOIDS

????

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>??????????????? (1 kPa) ?????? (50 kPa) ??????

>?????????????ò(??????????????????)

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> 3D ???????????:???? iPSC-CM ??????

SMART[Sphero] ?? ?C ???????

??????γɡ????????????·???????????

??????????? PEG ????????????,MSC ??????γ??????

??????????? PEG ????????????,MSC (GFP) ??????γ??????

?????????

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>???? 3D ???????????????????

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С?????????????,????? 22 С?

С?????????????,????? 12 ??

????

?????????????????????????????????Thomas????,2021 ,Developmental Cell 56,1498?C1511
????????????о?????????????????????????????Polonchuk, L., et al. ???????, 2017 7 (1), 7005
????????????????????????????
Khouri, MG, et al. δ???????, 2015 11 (4), 471-484
Bioinspired living structural color ?????Fu, F., et al. ?????????, 2018 3 (16), eaar8580
???п????е??????????????????Tse, JR, & Engler, AJ Current protocols in cell biology , 2010 47 (1) 10-16
?? 3D ????????????????????-??????????н???????????????????????????????Malinen, MM, et al. ???????, 2014 35 (19), 5110-5121.