生物力學相關產品及科研服務
- 多功能多軸向組織材料力學特性分析儀
- 微納自動壓痕儀
- 3D輪廓測量3D PROFILOMETRY
- Arthro-BST軟骨流動電位評估系統
- 組織材料摩擦磨損剪切模量測試系統
- biotester生物材料雙軸測試系統
- MicroSquisher多種微力測試分析系統
- UniVert單軸拉伸、壓縮和扭力測試分析
- Flexcell細胞拉壓流體剪切培養儀
- 單層細胞壓力加載培養與實時觀察分析系統
- TGT三維血管軟骨皮膚應力培養系統
- 血管生物反應器
- 肌腱韌帶生物反應器
- 軟骨生物反應器
- 旋轉灌流生物反應器
- 骨組織灌流表型生物反應器
- 皮膚生物反應器
- 凝膠支架種子細胞構建生物組織系統
- 皮膚彈性測試分析儀
- ITI單層細胞靜水壓力培養系統
- 細胞牽引力顯微鏡
- 細胞組織力學特性定量分析光鑷
- 離體或活體在體骨參考點壓痕測量分析儀
- 高通量細胞力學特性分析流式細胞儀
- 血管血流循環模擬系統
- VCU顱腦損傷儀
- 三維微流控芯片系統
- 更多
biomomentum多功能微觀生物力學系統之材料組織微力剪切力、摩擦磨損測試分析
多功能組織材料生物力學特性、電位分布測試分析表征系統
-多載荷多物理場耦合微觀力學性能原位測試系統
- 材料組織微力剪切、摩擦磨損測試分析
剪切shear
剪切試驗可用于評估平面剪切或扭轉中的材料的剪切模量g。 當在平行于其運動的方向上施加力時，剪切模量表示材料的剛度。 平衡剪切模量G被描述為剪切應變上的剪切應力。 兩種配置通常用于確定剪切模量：平面剪切，其遵循橫軸（x或y軸）和扭轉剪切，其遵循旋轉軸。 在平面剪切的構造下，假設樣品是一個的矩形棱鏡，其在應力下具有一個表面，其相對的表面受約束。 在扭轉剪切的構造下，假設樣品是一個的圓柱（慣性矯正力矩可以施加用于其他形狀），其頂部和底表面完Quan連接到兩個壓板（非滑動邊界條件）。
摩擦
摩擦測試確定兩個表面在接觸力作用下相互滑動的難易程度。在這些試驗中通常觀察到兩種主要現象:靜摩擦和動摩擦。靜摩擦力是阻止物體從靜止狀態移動的力，而動摩擦力是當兩個表面已經在運動時作用在它們之間的力。使用垂直平臺施加法向力，其他平臺施加旋轉或平移運動，由Biomomentum開發的軟件允許您輕松確定摩擦系數和測試中涉及的力。摩擦測試的目的涵蓋了一個很大的興趣領域。例如，測試一種新型潤滑劑的有效性或比較兩個樣品的表面性質。
壓痕亮點特點
1、力范圍跨度大：uN到250N
2、可以測試軟骨和隱形眼睛摩擦力
3、產品成熟，文獻量大（數百篇）
4、多力偶聯測試，如測量旋轉中兩個軟骨表面之間的摩擦系數
5、微力測試隱形眼睛摩擦測試
該系統是能集成壓縮、張力、剪切、摩擦、扭轉和2D/3D壓痕、3D輪廓及多力混合耦連測試的一體化微觀力學測試裝置。能對生物組織、聚合物、凝膠、生物材料、膠囊、粘合劑和食品進行精密可靠的機械刺激和表征。允許表征的機械性能包括剛度、強度、模量、粘彈性、塑性、硬度、附著力、腫脹和松弛位移控制運動。
特點
1、適用樣品范圍廣：
1.1、從骨等硬組織材料到腦組織、眼角膜等軟組織材料
1.2、從粗椎間盤的樣品到j細纖維絲
2、通高量壓痕測試分析
2.1、三維法向壓痕映射非平面樣品整個表面的力學特性
2.2、48孔板中壓痕測試分析
3、力學類型測試分析功能齊
模塊化集成壓縮、張力、剪切、摩擦、扭轉、穿刺、摩擦和2D/3D壓痕、3D表面輪廓、3D厚度、粘合、塔接結合力等各種力學類型支持,微觀結構表征及動態力學分析研究
4、高分辨率:
4.1、位移分辨率達0.1um
4.2、力分辨率 達0.025mN
5、 行程范圍廣：50-250mm
6、體積小巧、可放入培養箱內
7 、高變分辨率成像跟蹤分析
8、多軸向、多力偶聯刺激
9、活性組織電位分布測試分析
10、產品成熟，文獻量達 上千篇
該微觀力學測試分析與培養系統初該系統為軟骨力學性能檢測所研發，此后集成了多種配置以滿足更多生物組織和軟質材料力學性能的測量和評估。該儀器性能特點--模塊化設計，簡易操作平臺，面向用戶設計，廣泛應用于生物材料檢測，高分子材料檢測以及數字教學等領域，產品得到了業界廣泛的認可和推廣。該系統
相比于傳統的大型力學測試系統，該微觀力學測試系統總體較小，可以實現桌面化的操作流程，操作過程簡便。該系統測試方法面，是多樣化的材料力學表征工具，是科學家、工程師和其他各領域用戶的佳選擇。在動態力學分析、薄膜、復合物、聚合物、生物產品、醫學鑒定和水凝膠等領域都有廣泛應用。
Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly important for maintenance of the normally pristine articular surface. A boundary mode of lubrication is indicated by a kinetic friction coefficient being...
Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256
Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More
ASTM D1894 - Standard Test Method for Static and Kinetic Coefficients of Friction of Plastic Film and SheetingASTM International, West Conshohocken, PA, 2014,
Significance and Use
4.1 Measurements of frictional properties may be made on a film or sheeting specimen when sliding over itself or over another substance. The coefficients of friction are related to the slip properties of plastic films that are of wide interest in packaging applications. These methods yield empirical data for control purposes in film production. Correlation...Read More
ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009,
Abstract
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More
ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010,
Significance and Use
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
Mach-1 - Friction Testing on a Cartilage Disk or an Osteochondral Core (MA056-SOP08-D v2)Chartrａnd A and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 24th, 2015
Purpose
This procedure describes a standard method to realize a friction test on a cartilage disk or an osteochondral core using the Mach-1 TM mechanical tester.
Scope
This procedure can be used for the ex vivo friction test using a planar sliding method on a cartilage disk or an osteochondral...Read More
Mach-1 Analysis - Extraction of Mechanical Parameters Following Friction Testing on a Cartilage Disk or an Osteochondral Core (SW186-SOP07-D v2)Chartrａnd A and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 24h, 2015
Purpose
This procedure describes a MatLab-based method to extract mechanical parameters from the Mach-1 result files generated following friction testing on a cartilage disk or an osteochondral core as per MA056-SOP08-D.
Scope
This procedure based on a MatLab code can be applied using any Mach-1 result file obtained following a planar friction...Read More
Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)
There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More
Effect of synovial fluid on boundary lubrication of articular cartilageSchmidt TA and Sah RLOsteoarthritis Cartilage. 2007 Jan;15(1):35-47. Epub 2006 Jul 21
OBJECTIVES: The lubrication of articulating cartilage surfaces in joints occurs through several distinct modes. In the boundary mode of lubrication, load is supported by surface-to-surface contact, a feature that makes this mode particularly important for maintenance of the normally pristine articular surface. A boundary mode of lubrication is indicated by a kinetic friction coefficient...Read More
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin score, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More
Evaluation of genipin for stabilization of decellularized porcine cartilageElder S, Pinheiro A, Young C, Smith P and Wright EJ Orthop Res. 2016 Nov 18. doi: 10.1002/jor.23483
Abstract
We speculate that an acellular osteochondral xenograft may be a good alternative to allografts for repair of focal articular cartilage lesions. In order to make a xenograft resistant to enzymatic degradation and to prevent a chronic immune response it may beneficial to stabilize it through crosslinking. The concept is analogous to treatment of porcine bioprosthetic heart...Read More
Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428
Engineering of Hyaline Cartilage with a Calcified Zone Using Bone Marrow Stromal CellsLee WD, Hurtig MB, Pilliar RM, Stanford WL and Kandel RAOsteoarthritis and Cartilage (2015), doi: 10.1016/j.joca.2015.04.010
In healthy joints, a zone of calcified cartilage (ZCC) provides the mechanical integration between articular cartilage and subchondral bone. Recapitulation of this architectural feature should serve to resist the constant shear force from the movement of the joint and prevent the delamination of tissue-engineered cartilage. Previous approaches to create the ZCC at the cartilage-substrate interface...Read More
The shear mechanical properties of diabetic and non-diabetic plantar soft tissuePai S and Ledoux WRJournal of biomechanics, 45(2), 364-370. (2012)
Changes in the plantar soft tissue shear properties may contribute to ulceration in diabetic patients, however, little is known about these shear parameters. This study examines the elastic and viscoelastic shear behavior of both diabetic and non-diabetic plantar tissue. Previously compression tested plantar tissue specimens (n = 54) at six relevant plantar locations (hallux, first, third, and fifth...Read More
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More
ASTM C273/C273M - Standard Test Method for Shear Properties of Sandwich Core MaterialsASTM International, West Conshohocken, PA, 2016,
Significance and Use
5.1 The core shear properties are fundamental properties that are used in the design of sandwich panels. This test method provides information on the force-deflection behavior of sandwich constructions or cores when loaded in shear parallel to the plane of the facings. From a complete force-deflection curve, it is possible to compute core shear stress at...Read More
ASTM F2451-05 - Standard Guide for in vivo Assessment of Implantable Devices Intended to Repair or Regenerate Articular CartilageASTM International, West Conshohocken, PA, 2010,
Significance and Use
This guide is aimed at providing a range of in vivo models to aid in preclinical research and development of tissue engineered medical products intended for the clinical repair or regeneration of articular cartilage.
This guide includes a description of the animal models, surgical considerations, and tissue processing as well as the qualitative and quantitative...Read More
Mach-1 - Shear Testing on a Cartilage Disk or an Osteochondral Core (MA056-SOP07-D v2)Tessier J and Quenneville EBiomomentum Inc. Laval (QC), Canada, Effective Date: August 25th, 2015
Purpose
This procedure describes a standard method to realize a planar or a torsion shear test on an articular cartilage disk or an osteochondral core using the Mach-1TM mechanical tester.
Scope
This procedure can be used for the ex vivo planar or torsion test on an articular cartilage core or an osteochondral core. It is highly...Read More
Mach-1 Analysis - Extraction of Mechanical Parameters Following Shear Testing on a Cartilage Disk or an Osteochondral Core (SW186-SOP06-D v1)Lavallée APBiomomentum Inc. Laval (QC), Canada, Effective Date: August 19th, 2015
Purpose
This procedure describes a method to extract mechanical parameters from Mach-1 result files generated following shear testing on a cartilage disk or an osteochondral core as per MA056-SOP07-D.
Scope
This procedure can be applied using any Mach-1 result file obtained following a planar shear or a torsion test on a sample. Some...Read More
Tailoring hydrogel surface properties to modulate cellular response to shear loadingMeinert C, Schrobback K, Levett PA, Lutton C, Sah R and Klein TJActa biomaterialia, October 2016. DOI: 10.1016/j.actbio.2016.10.011
Biological tissues at articulating surfaces, such as articular cartilage, typically have remarkable low-friction properties that limit tissue shear during movement. However, these frictional properties change with trauma, aging, and disease, resulting in an altered mechanical state within the tissues. Yet, it remains unclear how these surface changes affect the behaviour of embedded cells when the...Read More
Mechanical characterization of matrix-induced autologous chondrocyte implantation (MACI®) grafts in an equine model at 53 weeksGriffin DJ, Bonnevie ED, Lachowsky DJ, Hart JC, Sparks HD, Moran N and Bonassar LJJournal of biomechanics, 48(10), 1944-1949. (2015)
There has been much interest in using autologous chondrocytes in combination with scaffold materials to aid in cartilage repair. In the present study, a total of 27 animals were used to compare the performance of matrix-assisted chondrocyte implantation (MACIs) using a collagen sponge as a chondrocyte delivery vehicle, the sponge membrane alone, and empty controls. A total of three distinct types of...Read More
Change in viability of C2C12 myoblasts under compression, shear and oxidative challengesHong Y, Yao Y, Wong S, Bian L and Mak AFJournal of biomechanics, 49(8), 1305-1310. (2016)
Skeletal and epidermal loadings can damage muscle cells and contribute to the development of deep tissue injury (DTI) – a severe kind of pressure ulcers affecting many people with disability. Important predisposing factors include the multiaxial stress and strain fields in the internal tissues, particularly the vulnerable muscles around bony prominences. A careful study of the mechanical damage thresholds...Read More
Characterization of tissue engineered cartilage products - Recent developments in advanced therapyMaciulaitis J, Rekstyte S, Usas A, Jankauskaite V, Gudas R, Malinauskas M and Maciulaitis RPharmacological Research 113 (2016) 823–832
Legislative requirements for the quality of pharmacological agents underwent certain evolution when new type of therapies emerged. This relates to cell based medicines, such as tissue engineered cartilage products (TECP) which are increasingly developed as new modalities for widely prevalent orthopaedic disorders. Although quality measures for TECP are subject to the same general regulatory quality...Read More
Review Paper: Fifty years of brain tissue mechanical testing: From in vitro to in vivo investigationsChatelin S, Constantinesco A and Willinger RBiorheology 47 (2010) 255–276. DOI 10.3233/BIR-2010-0576
Beginning in the 1960s many studies have been performed to investigate the mechanical properties of brain. In this paper we point out the difficulties linked with in vitro experimental protocols as well as the advantages of using recently developed non-invasive in vivo techniques, such as magnetic resonance elastography. Results of in vitro and in vivo work are compared, emphasizing the specificities...Read More
Combined Mechanical Characterizations Increases Sensitivity in the Assessment of Human Cartilage DegenerationSim S, Hadjab I, Chevrolat L-A, Masse M, Tong AL, Lavigne P, Garon M, Quenneville E and Buschmann MDAccepted for a podium presentation at ORS 2017
Introduction: We published a recent study showing superior sensitivity of electromechanical and indentation (instantaneous response) assessments versus well-established techniques, including histological Mankin score, to characterize cartilage degeneration. This study aims to determine whether the combination of instantaneous, relaxation and equilibrium mechanical properties and friction...Read More
Autonomously Self-Adhesive Hydrogels as Building Blocks for Additive ManufacturingDeng X, Attalla R, Sadowski LP, Chen M, Majcher MJ, Urosev I, Yin D-C, Selvaganapathy PR, Filipe CDM and Hoare TBiomacromolecules 2018 19 (1), 62-70 doi: 10.1021/acs.biomac.7b01243
We report a simple method of preparing autonomous and rapid self-adhesive hydrogels and their use as building blocks for additive manufacturing of functional tissue scaffolds. Dynamic crosslinking between 2-aminophenylboronic acid-functionalized hyaluronic acid and poly(vinyl alcohol) yields hydrogels that recover their mechanical integrity within one minute after cutting or shear under both neutral...Read More
Quantitative Analysis of Tissue Damage Evolution in Porcine Liver With Interrupted Mechanical Testing Under Tension, Compression, and Shear.Chen J, Brazile B, Prabhu R, Patnaik SS, Bertucci R, Rhee H, Horstemeyer MF, Hong Y, Williams LN, Liao JJ Biomech Eng. 2018 Jul 1;140(7). doi: 10.1115/1.4039825.
In this study, the damage evolution of liver tissue was quantified at the microstructural level under tensile, compression, and shear loading conditions using an interrupted mechanical testing method. To capture the internal microstructural changes in response to global deformation,...Read More
Shear-Deformation Based Continuum-Damage Constitutive Modeling of Brain TissueMark T. Begonia, Alexander M. Knapp, R.K. Prabhu, Jun Liao and Lakiesha N. WilliamsJournal of Biomechanics, 2021, 110260, ISSN 0021-9290, https://doi.org/10.1016/j.jbiomech.2021.110260
Abstract: Traumatic brain injury (TBI) is a leading cause of death in the United States. Depending on the severity of injury, complications such as memory loss and emotional changes are common. While the exact mechanisms are still unclear, these cognitive deficiencies are thought to arise from microstructural damages to the brain tissue, such as in diffuse-axonal injury where neuron fibers...Read More
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