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上海研盟生物科技有限公司
上海研盟生物科技有限公司
“Anti-phospho-ATF2抗體,磷酸化活化復制因子2抗體抗體規格0.1ml、0.2ml、1ml，抗體產品有效期一年，質保三個月，質保期內出現任何質量問題或是出不了實驗結果均可免費退換：
上海研盟生物科技有限公司Anti-phospho-ATF2抗體,磷酸化活化復制因子2抗體*，主要應用于WB、IHC、IF、ELISA、流式細胞術等實驗中。說明書隨貨發送，您也可以直接我司在線客服索取。客服
簡單介紹：
中文名稱：磷酸化活化復制因子2抗體
英文名稱：Anti-phospho-ATF2
產品編號：byk-1648R
產品別名：ATF2 (phospho S490); p-ATF2 (phospho S490); ATF2 (phospho S490 + S498); p-ATF2 (phospho S490 + S498); CREB 2; HB 16;Activating Transcription Factor 2; ATF 2; Atf-2; ATF2 protein; cAMP Response Element Binding Protein 2; cAMP response element binding protein CRE BP1; cAMP-dependent transcription factor ATF-2; cAMP-responsive element-binding protein 2; CRE BP1; CRE-BP; CREB 2; CREB2; CREBP1; Cyclic AMP dependent transcription factor ATF 2; Cyclic AMP-responsive.
產品用途：科研實驗
產品價格：請報價
說明書：請添加客服直接索取
抗體來源：該指標有兩種產品，一種是兔來源抗體，一種是鼠來源抗體
克隆類型：兔來源為多克隆抗體，鼠來源單克隆抗體
交叉反應：請索取說明書查看
性 狀：Lyophilized or Liquid
濃 度：1mg/1ml
亞 型:IgG
純化方法: affinity purified by Protein A
儲 存 液: 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol
保存條件: Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Anti-phospho-ATF2抗體,磷酸化活化復制因子2抗體產品介紹：ATF2 is a member of the ATF/CREB family of basic region leucine zipper DNA binding proteins that regulates transcription by binding to a consensus cAMP response element (CRE) in the promoter of various viral and cellular genes. Many of these genes are important in cell growth and differentiation, and in stress and immune responses. ATF2 is a nuclear protein that binds DNA as a dimer and can form dimers with members of the ATF/CREB and Jun/Fos families. It is a stronger activator as a heterodimer with cJun than as a homodimer. Several isoforms of ATF2 arise by differential splicing. The stable native full length ATF2 is transcriptionally inactive as a result of an inhibitory direct intramolecular interaction of its carboxy terminal DNA binding domain with the amino terminal transactivation domain. Following dimerization ATF2 becomes a short lived protein that undergoes ubiquitination and proteolysis, seemingly in a protein phosphatase-dependent mechanism. Stimulation of the transcriptional activity of ATF2 occurs following cellular stress induced by several genotoxic agents, inflammatory cytokines, and UV irradiation. This activation requires phosphorylation of two threonine residues in ATF2 by both JNK/SAP kinase and p38 MAP kinase. ATF2 is abundantly expressed in brain.
免疫組化的呈色深淺可反映抗原存在的數量，可作為定性、定位和定量的依據。
1.陽性細胞染色分布有三種類型：細胞漿、細胞核、細胞膜表面。大部分抗原見于細胞漿，可見于整個胞漿或部分胞漿
2.陽性細胞分布可分為灶型和彌漫性
3.由于細胞內含抗原量不同，所以染色強度不一。如果細胞之間染色強度相同，常提示其反應為非特異性
4.陽性細胞染色定位于單個細胞，且與陰性細胞相互交雜分布；而非特異性染色常不限于單個細胞，而是累及一片細胞。
5.切片邊緣、刀痕或褶皺區域，壞死或擠壓的細胞區，膠原結締組織等，常表現為相同的陽性染色強度，不能用于判斷陽性。
相關產品：
Integrin a7（integrin alpha 7） 整合素α7抗體
Integrin β1/CD29(integrin beta 1) 整合素β1抗體
Integrin α5/CD49e/VLA-5（Integrin αV） 整合素α5抗體
Integrin α6/CD49f/VLA-6(Integrin alpha6/Laminin Receptor) 整合素α6抗體
Integrin β3/CD61(Integrin beta 3) 整合素β3抗體
JAK1(Tyrosine-protein kinase JAK1; Janus kinase 1) 蛋白質*激酶JAK-1抗體
JAK2(Tyrosine-protein kinase JAK2; Janus kinase 2; JAK-2) 蛋白質*激酶JAK-2抗體
phospho JAK2(phospho-Tyr1007+Tyr1008) 磷酸化蛋白*激酶JAK-2抗體
JNK1/3 (c-Jun amino-terminal kinase 1/3) c-Jun氨基末端激酶1/3抗體
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phospho-JNK1/2/3(pThr183/pTyr185) 抗磷酸化氨基末端激酶1/2/3抗體
JNK1/2/3 抗氨基末端激酶1/2/3抗體
p300/KAT3B 轉錄接頭蛋白EP300抗體
KCNA5(Potassium voltage-gated channel subfamily A member 5) 鉀電壓閥門通道混合器相關亞家族成員5抗體
Ki-67 Ki-67 Antigen抗體
Ki-67（Antigen identified by monoclonal antibody Ki 67） Ki67抗體
Ki-67（mo monoclonal） 小鼠Ki-67單克隆抗體
Kif14 protein 驅動蛋白家族Member14蛋白抗體
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