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Human EGF Recombinant Protein Carrier-Free

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產品型號100 ug

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更新時間：2017-08-04 04:00:24瀏覽次數：827次

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產品簡介

Human EGF Recombinant Protein Carrier-Free
Also known as: Epidermal Growth Gactor
RUO: For Research Use Only. Not for use in diagnostic procedures.

詳細介紹

Description: EGF （Epidermal Growth Factor） is a member of the EGF-like family of proteins. It stimulates the growth and differentiation of fibroblasts and epithelial cells, and plays a role in the development and regeneration of various tissues. EGF, like many of the other members of this family, it is synthesized as a precursor protein that remains anchored to the cell surface. Release of the soluble form occurs through a process known as ectodomain shedding, which involves cleavage of the extracellular domain by the proteins disintegrin and ADAM17. EGF signals via EGF Receptor （EGFr, ErbB1, or HER1）, which is a type 1 tyrosine kinase receptor and can also bind several other EGF-like proteins. Binding of EGF to EGFr triggers receptor dimerization, autophosphorylation, and internalization of the receptor-ligand complex. EGF and its receptor are often overexpressed in malignant tumors, and are considered potential targets for cancer therapy.