Rabbit Anti-Fibrinogen

Quantity size :   0.1ml  （dilute with pH 7.4  0.01 M PBS or antibody diluent ）

Background:   Fibrinogen is the main protein of blood coagulation system. It is a large

protein and it consists of two identical subunits that contain three polypeptide chains:

alpha, beta and gamma. All chains are connected with each other by a number of disulfide

bonds. Fibrinopeptides A （1 to 16 amino acids） and B （1 to 17 amino acids） are released

by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way

fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot.

Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of

arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen

activation is also involved in pathogenesis of inflammation, tumor growth and many other

diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated

level of fibrinogen in patient's blood is  regarded as an independent risk factor for

cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a

strong predictor of coronary heart disease （Sonel A. et al, and Rapold H.J. et al）. All these

facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.

Specificity :      · anti- Fibrinogen is a rabbit polyclonal antibody unconjugated

                · specific for Fibrinogen of human  

                · epitope mapping near the amino terminus of Fibrinogen of human, 

                · use for western blotting, elisa, immunoprecipitation  

                  and immunohistochemistry

·Protein G affinity chromatography purification, purity :>95%

·Isotype: IgG

Application :     · Western blotting: 1:100-500

                · Immunohistochemistry: 1:100-500

                · ELISA: 1:500-1000 

                · Optimal working dilutions must be determined by the end user.

Storage:        Store at –20 oC for one year. Avoid repeated freeze/thaw cycles. The

lyophilized antibody is stable at room temperature for at least one month and for greater

than a year when kept at -20oC. When reconstituted in sterile pH 7.4 0.01M PBS or diluent

of antibody, the antibody is stable for at least two weeks at 2-4 oC.

Important Note: This product as supplied is intended for research use only, not for use in

human, therapeutic or diagnostic applications.

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