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上海勁馬實驗設備有限公司
中級會員·17年
具體成交價以合同協議為準
- 聯系人：
- 馮經理
- 電話：
- 021-60521817
- 手機：
- 13817140470
- 售后：
- 86-021-61107441
- 傳真：
- 86－021－64881400
- 地址：
- 上海市松江區漕河涇研展路455號B座
- 個性化：
- www.shjmsw.com
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- m.shjmsw.com
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產品介紹
Description
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Biochem/physiol Actions Naturally fluorescent anthracycline antibiotic, anticancer drug. Doxorubicin is a substrate of MRP1 which was first cloned from a DOX-resistant lung cancer cell line. Fluorescent property has been exploited for the measurement of drug efflux pump activities as well as resolving the important question of intracellular localization of various multidrug resistance proteins and the role of subcellular organelles （Golgi and lysosome） in the sequestration of drugs and its implication in drug resistant phenotypes.
Antitumour antibiotic. Effect of adriamycin on heart mitochondrial DNA;1 Properties.2,3
Inhibitor of reverse transcriptase and RNA polymerase; immunosuppressive agent; intercalates in DNA.
Legal Information Adriamycin is a registered trademark of Farmitalia Carlo Erba S.R.L.
Properties
assay ≥98% （TLC）
mp 216 °C （dec.）（lit.）
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, full-face particle respirator type N100 （US）, Gloves, respirator cartridge type N100 （US）, type P1 （EN143） respirator filter, type P3 （EN 143） respirator cartridges
Hazard Codes T
Risk Statements 45-22
Safety Statements 53-45
WGK Germany 3
RTECS QI9295900
References
Cited Reference 1. C.N. Ellis et al. Biochem. J. 245, 309, （1987）
2. R.J. White et al. Drugs Pharm. Sci. 22, 569, （1984）
3. A. Vigevani, M.J. Williamson Anal. Profiles Drug Subst. 9, 245, （1980）
reference Gong, Y., et al. J. Biol. Chem. 278, 50234-50239, （2003） Abstract
Rajagopal, A., and Simon, S.M. Mol. Biol. Cell 14, 3389-3399, （2003） Abstract
Friesen, C., et al., Cytotoxic drugs and the CD95 pathway. Leukemia 13, 1854, （1999）
Kraus-Berthier, L, et al., Histology and sensitivity to anticancer drugs of two human non-small cell lung carcinomas implanted in the pleural cavity of nude mice. Clin. Cancer Res. 6, 297-304, （2000）
Sparano, J.A., Doxorubicin/taxane combinations: cardiac toxicity and pharmacokinetics. Semin. Oncol. 26, 14-19, （1999）
Merck Merck 13,3473
Aldrich MSDS 1, 849:A / Corp MSDS 1 （1）, 1499:A / RegBook 1 （2）, 1691:D / Sax 6, 144 / Structure Index 1, 268:B:6
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