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產品介紹
Description
Biochem/physiol Actions Pepstatin A is an inhibitor of acid proteases （aspartyl peptidases）. It forms a 1:1 complex with proteases such as pepsin, renin, cathepsin D, bovine chymosin, and protease B （Aspergillus niger）. The inhibitor is highly selective and does not inhibit thiol proteases, neutral proteases, or serine proteases. Solubilized γ-secretase and retroviral protease are also inhibited by Pepstatin A. It has been used to characterize proteases from several sources.
Preparation Note Pepstatin can be dissolved at 1 mg/ml in 10% （v/v） acetic acid in methanol （9:1 methanol:acetic acid）. The inclusion of acetic acid may be necessary to dissolve this peptide in methanol or DMSO. It has been dissolved at 1 to 2 mg/ml in ethanol, but heat may be required for complete dissolution. Solutions of Pepstatin A can be heated as high as 60 °C without any decomposition of the peptide.
Stock solutions at 1 mg/ml are stable at least a week at 4 °C. A 1 mM solution in methanol or DMSO is stable for months at -20 °C. If solutions become darker yellow, the reagent is hydrolyzing.
A working concentration of 1 μM is stable for at least one day at room temperature.
Properties
biological source microbial
assay ≥75% （HPLC）
mp 233 °C （dec.）（lit.）
storage temp. 2-8°C
Safety
Personal Protective Equipment Eyeshields, Gloves, type N95 （US）, type P1 （EN143） respirator filter
Safety Statements 22-24/25
WGK Germany 2
RTECS SC6155000
References
reference Deutscher, M.P. Meth. Enzymol. 182, 83-89, （1990）
Rich, D.H., et al. Biochemistry 24, 3165, （1985）
Gegenheimer, P. Meth. Enzymol. 182, 174-193, （1990）
Merck Merck 13,7226
FT-IR 2 （1）, 1336:A / RegBook 1 （1）, 921:E / Sax 6, 2143 / Structure Index 1, 143:D:2
Printable Reviews
Product ReviewsReview This Product
中文名稱: 抑肽素
中文同義詞: 抑肽素;胃蛋白酶抑制劑;胃酶抑素
英文名稱: Pepstatin
英文同義詞: ahpatininc;pepsininhibitors735a;procidins735a;PEPSTATIN;PEPSTATIN A;X-VAL-VAL-STATYL-ALA-STATIN;（3S,4S）-4-AMINO-3-HYDROXY-6-METHYL-HEPTANOIC ACID;AHMHA ISOVALERYL-L-VAL-L-VAL-AHMHA-L-ALA-STA
CAS號: 26305-03-3
分子式: C34H63N5O9
分子量: 685.89
EINECS號: 247-600-0
相關類別: 輔酶/酶
Mol文件: 26305-03-3.mol
抑肽素 性質
熔點 233 °C （dec.）（lit.）
儲存條件 2-8°C
溶解度 10% acetic acid in methanol: 1 mg/mL
穩定性 Stable. Incompatible with strong bases, strong acids.
CAS 數據庫 26305-03-3（CAS DataBase Reference）
安全信息
安全說明 22-24/25
WGK Germany 2
RTECS號 SC6155000
F 10
