Pepsinogen II胃蛋白酶原C抗體相關標記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC      
英文名稱    Pepsinogen II
中文名稱    胃蛋白酶原C抗體
別    名    PG-C; Pepsinogen C; Progastricsin; Pepsinogen II; Pepsinogen-2; Pepsinogen2; PEPC_HUMAN; Gastricsin; Pepsinogen C; PEPC; pepsin C; pepsinogen group II; PGC; PGII; preprogastricsin.
研究領域    腫瘤  信號轉導  腫瘤細胞生物標志物  
抗體來源    Rabbit
克隆類型    Polyclonal
交叉反應    Human, Mouse, Rat, Chicken, Cow, 
Pepsinogen II胃蛋白酶原C抗體產品應用    WB=1:100-500 ELISA=1:500-1000 IP=1:20-100 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500  （石蠟切片需做抗原修復） 

not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量    42kDa
細胞定位    分泌型蛋白 
性    狀    Lyophilized or Liquid
濃    度    1mg/1ml
免 疫 原    KLH conjugated synthetic peptide derived from human PG-C
亞    型    IgG
純化方法    affinity purified by Protein A
儲 存 液    0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
保存條件    Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹    background:
This gene encodes an aspartic proteinase that belongs to the peptidase family A1. The encoded protein is a digestive enzyme that is produced in the stomach and constitutes a major component of the gastric mucosa. This protein is also secreted into the serum. This protein is synthesized as an inactive zymogen that includes a highly basic prosegment. This enzyme is converted into its active mature form at low pH by sequential cleavage of the prosegment that is carried out by the enzyme itself. Polymorphisms in this gene are associated with susceptibility to gastric cancers. Serum levels of this enzyme are used as a biomarker for certain gastric diseases including Helicobacter pylori related gastritis. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq].

Function:
Hydrolyzes a variety of proteins.

Subcellular Location:
Secreted.

Similarity:
Belongs to the peptidase A1 family.

Gene ID:
5225

Database links:
Entrez Gene: 5225 Human
Entrez Gene: 24864 Rat
Omim: 169740 Human
SwissProt: P20142 Human
SwissProt: P04073 Rat
Unigene: 1867 Human
Unigene: 9735 Rat

Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. 

胃蛋白酶原C(PG-C)主要用于胃癌及其癌前病變易感性的關系。