Anti-ABCG2 三磷酸腺苷結合轉運蛋白G超家族成員2抗體相關標記     Alexa Fluor 350   Alexa Fluor 488   Alexa Fluor 555   Alexa Fluor 647   AP   APC   Biotin  Cy3   Cy5  
 Cy5.5   Cy7   FITC   Gold   HRP   PE   PE-Cy3   PE-CY5   PE-CY5.5   PE-CY7   RBITC 英文名稱     Anti-ABCG2
中文名稱     三磷酸腺苷結合轉運蛋白G超家族成員2抗體
別    名     ABC15; ABCG 2; ABCG2; ABCG2_HUMAN; ABCP; ATP binding cassette sub family G (WHITE) member 2; ATP binding cassette transporter G2; ATP-binding cassette sub-family G member 2; BCRP1; BMDP; Breast cancer resistance protein; CD338; CDw338; CDw338 antigen; EST157481; GOUT1; MGC102821; Mitoxantrone resistance associated protein; Mitoxantrone resistance-associated protein; MRX; Multi drug resistance efflux transport ATP binding cassette sub family G (WHITE) member 2; MXR; MXR1; Placenta specific ATP binding cassette transporter; Placenta specific MDR protein; Placenta-specific ATP-binding cassette transporter; UAQTL1. 
抗體來源     Rabbit
克隆類型     polyclonal
Anti-ABCG2 三磷酸腺苷結合轉運蛋白G超家族成員2抗體交叉反應     Human, Mouse, Rat, 
產品類型     一抗  
研究領域     免疫學 神經生物學 干細胞 轉運蛋白 細胞表面分子
蛋白分子量     predicted molecular weight: 72kDa
性    狀     Lyophilized or Liquid
免 疫 原     KLH conjugated synthetic peptide derived from human ABCG2
亞    型     IgG
純化方法     affinity purified by Protein A
儲 存 液     0.01M PBS, pH 7.4 with 10 mg/ml BSA and 0.1% Sodium azide
產品應用      WB=1:100-500  ELISA=1:500-1000  IP=1:20-100  IHC-P=1:100-500  IHC-F=1:100-500  IF=1:100-500 
（石蠟切片需做抗原修復） 

 not yet tested in other applications.
 optimal dilutions/concentrations should be determined by the end user.
保存條件     Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
Important Note     This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產品介紹    An ABC transporter. Allows efflux of Hoechst dye, a property that has been used to separate bone marrow side population cells, which express BCRP/ABCG2. Appears to play a major role in the multidrug resistance phenotype of a specific MCF-7 breast cancer cell line. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Breast Cancer Resistance Protein (BCRP) is a 70 kDa ATP-Binding Cassette membrane transport protein involved in multidrug resistance. BCRP may be over-expressed in cancer cell lines selected with doxorubicin / verapamil, topotecan or mitoxantrone.

Function : Xenobiotic transporter that may play an important role in the exclusion of xenobiotics from the brain. May be involved in brain-to-blood efflux. Appears to play a major role in the multidrug resistance phenotype of several cancer cell lines. When overexpressed, the transfected cells become resistant to mitoxantrone, daunorubicin and doxorubicin, display diminished intracellular accumulation of daunorubicin, and manifest an ATP-dependent increase in the efflux of rhodamine 123.
Subunit : Monomer or homodimer; disulfide-linked.
Subcellular Location : Cell membrane; Multi-pass membrane protein.
Tissue Specificity : Highly expressed in placenta. Low expression in small intestine, liver and colon.
Similarity : Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Contains 1 ABC transmembrane type-2 domain.
Contains 1 ABC transporter domain.
Database links :
UniProtKB/Swiss-Prot: Q9UNQ0.3
Entrez Gene: 9429 Human
Omim: 603756 Human
SwissProt: Q9UNQ0 Human
Unigene: 480218 Human

Hematopoietic/Neural Stem Cell Marker （造血/神經干細胞標志物)