在殺死癌細(xì)胞的同時(shí)，也殺死了正常細(xì)胞。”這個(gè)困惑著*醫(yī)生和癌癥病人的難題，終于可望破解。筆者13日從中山大學(xué)獲悉，中山大學(xué)中山醫(yī)學(xué)院教授顏光美課題組于7日在期刊《美國(guó)科學(xué)院院報(bào)》發(fā)表了天然甲病毒M1具有選擇性抗腫瘤作用的研究，該研究表明，一種叫做M1的天然病毒能特異性殺死癌細(xì)胞而不傷害正常細(xì)胞，這種新型溶瘤病毒有望成為新一代抗癌利器

XY-EL-P0345c    豬血清素轉(zhuǎn)運(yùn)體(SERT)ELISA試劑盒    Porcine SERT (Serotonin Transporter ) ELISA Kit 
XY-EL-P0346c    豬葡萄糖轉(zhuǎn)運(yùn)蛋白2(GLUT2)ELISA試劑盒    Porcine GLUT2 (Glucose Transporter 2) ELISA Kit
XY-EL-P0347c    豬Rap鳥(niǎo)嘌呤交換因子1(RAPGEF1)ELISA試劑盒    Porcine RAPGEF1 (Rap Guanine Nucleotide Exchange Factor 1) ELISA Kit 
XY-EL-P0348c    豬核因子κB抑制蛋白β(IκBβ)ELISA試劑盒    Porcine IκBβ (Inhibitory Subunit of NF Kappa B Beta) ELISA Kit 
XY-EL-P0349c    豬微管相關(guān)蛋白2(MAP-2)ELISA試劑盒    Porcine MAP-2 (Microtubule Associated Protein 2) ELISA Kit
XY-EL-P0350c    豬6酮前列腺素(6-K-PG)ELISA試劑盒     Porcine 6-K-PG (6-Keto-prostaglandin) ELISA Kit
XY-EL-P0351c    豬原卟啉(EPP)ELISA試劑盒    Porcine EPP (Erythrocyte Protoporphyrin) ELISA Kit
XY-EL-P0352c    豬神經(jīng)營(yíng)養(yǎng)因子4(NT-4)ELISA試劑盒    Porcine NT-4 (Neurotrophin 4) ELISA Kit 
XY-EL-P0353c    豬核孔蛋白205kda(NUP205)ELISA試劑盒    Porcine NUP205 (Nucleoporin 205kDa) ELISA Kit
XY-EL-P0354c    豬腫瘤壞死因子受體超家族成員1A(TNFRSF1A)ELISA試劑盒    Porcine TNFRSF1A (Tumor Necrosis Factor Receptor Superfamily, Member 1A) ELISA Kit
XY-EL-P0356c    豬接觸蛋白2(CNTN2)ELISA試劑盒    Porcine CNTN2 (Contactin 2) ELISA Kit 
XY-EL-P0357c    豬醛縮酶(ALD)ELISA試劑盒     Porcine ALD (Aldolase) ELISA Kit
XY-EL-P0358c    豬胰島素樣生長(zhǎng)因子1受體(IGF1R)ELISA試劑盒    Porcine IGF1R (Insulin Like Growth Factor 1 Receptor) ELISA Kit
XY-EL-P0360c    豬水通道蛋白2(AQP-2)ELISA試劑盒     Porcine AQP-2 (Aquaporin 2) ELISA Kit 
XY-EL-P0362c    豬酸性磷酸酶1(ACP1)ELISA試劑盒     Porcine ACP1 (Acid Phosphatase 1) ELISA Kit
XY-EL-P0363c    豬延伸蛋白A(EloA)ELISA試劑盒     Porcine EloA (Elongin A) ELISA Kit
XY-EL-P0364c    豬絲氨酸蛋白酶23(PRSS23)ELISA試劑盒    Porcine PRSS23 (Protease, Serine 23) ELISA Kit 
XY-EL-P0365c    豬八聚體結(jié)合轉(zhuǎn)錄因子1(OBTF1)ELISA試劑盒    Porcine OBTF1 (Octamer Binding Transcription Factor 1) ELISA Kit 
XY-EL-P0366c    豬組織蛋白酶C(CTSC)ELISA試劑盒      Porcine CTSC (Cathepsin C) ELISA Kit
XY-EL-P0367c    豬神經(jīng)絲蛋白(NF)ELISA試劑盒    Porcine NF (Neurofilament) ELISA Kit
XY-EL-P0369c    豬肌肉磷酸果糖激酶(PFKM)ELISA試劑盒     Porcine PFKM (Phosphofructokinase, Muscle) ELISA Kit
XY-EL-P0370c    豬硫氧化還原蛋白(Trx)ELISA試劑盒    Porcine Trx (Thioredoxin) ELISA Kit
XY-EL-P0372c    豬重肽鐵蛋白(FTH)ELISA試劑盒    Porcine FTH (Ferritin, Heavy Polypeptide) ELISA Kit 
XY-EL-P0373c    豬葡萄糖6磷酸異構(gòu)酶(GPI)ELISA試劑盒      Porcine GPI (Glucose 6 Phosphate Isomerase) ELISA Kit
XY-EL-P0374c    豬絲裂原激活蛋白激酶激酶6(MAP2K6/MKK6)ELISA試劑盒    Porcine MAP2K6/MKK6 (Mitogen Activated Protein Kinase Kinase 6) ELISA Kit
XY-EL-P0375c    豬心肌營(yíng)養(yǎng)素樣細(xì)胞因子1(CLCF1)ELISA試劑盒     Porcine CLCF1 (Cardiotrophin Like Cytokine Factor 1) ELISA Kit 
XY-EL-P0376c    豬錨蛋白B(Ank-B)ELISA試劑盒     Porcine Ank-B (Ankyrin B) ELISA Kit
XY-EL-P0377c    豬白細(xì)胞分化抗原CD97(CD97)ELISA試劑盒     Porcine CD97 (Cluster of Differentiation 97) ELISA Kit 
XY-EL-P0379c    豬二氫嘧啶酶樣2(DPYSL2)ELISA試劑盒     Porcine DPYSL2 (Dihydropyrimidinase Like Protein 2) ELISA Kit
XY-EL-P0380c    豬鈣周期蛋白結(jié)合蛋白(CACYBP)ELISA試劑盒    Porcine CACYBP (Calcyclin Binding Protein) ELISA Kit 
XY-EL-P0382c    豬環(huán)腺苷二磷酸核糖水解酶(cADPRH/CD38)ELISA試劑盒    Porcine cADPRH/CD38 (Cyclic ADP Hydrolase) ELISA Kit
XY-EL-P0383c    豬轉(zhuǎn)錄激活因子-1(ATF-1)ELISA試劑盒     Porcine ATF-1 (Activating Transcription Factor 1) ELISA Kit
XY-EL-P0384c    豬速激肽受體2(TACR2)ELISA試劑盒    Porcine TACR2 (Tachykinin Receptor 2) ELISA Kit
XY-EL-P0385c    豬補(bǔ)體受體2 (CR2/CD21)ELISA試劑盒     Porcine CR2/CD21 (Complement Receptor 2) ELISA Kit

癌癥發(fā)病率呈現(xiàn)快速增長(zhǎng)態(tài)勢(shì)，現(xiàn)有的治療手段遠(yuǎn)遠(yuǎn)未能滿(mǎn)足臨床需求。顏光美課題組歷經(jīng)多年研究，從海南島分離得到一種M1的天然病毒。顏光美團(tuán)隊(duì)使用細(xì)胞培養(yǎng)方法發(fā)現(xiàn)，M1病毒能選擇性地感染并殺死包括肝癌、結(jié)直腸癌、膀胱癌、黑色素瘤在內(nèi)的多種癌細(xì)胞，而對(duì)正常細(xì)胞無(wú)毒副作用。整體動(dòng)物模型證明，M1病毒“像長(zhǎng)了眼睛一樣準(zhǔn)確找到腫瘤組織并將其殺滅”，正常細(xì)胞則不受影響。

除細(xì)胞水平及動(dòng)物實(shí)驗(yàn)之外，課題組還使用臨床標(biāo)本離體活組織培養(yǎng)模型進(jìn)一步證實(shí)了上述新型溶瘤病毒的有效性和特異性