CD26檢測試劑盒

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公司名稱上海谷博實業有限公司
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型號BML-AK499
所在地上海市
廠商性質代理商
更新時間2018/4/29 5:07:15
訪問次數2408

產品標簽:

DPP4 DPPIV 二肽基肽酶4 二肽基肽酶IV ADCP-2

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CD26檢測試劑盒；DPP4,DPPIV,二肽基肽酶4,二肽基肽酶IV,ADCP-2,CD26,ADABP,ADCP2,TP103

CD26檢測試劑盒產品信息

CD26檢測試劑盒

DPP4,DPPIV,二肽基肽酶4,二肽基肽酶IV,ADCP-2,CD26,ADABP,ADCP2,TP103

貨號BML-AK499

DPPIV drug discovery kit Enzo lifescience BML-AK499；二肽基肽酶 4 /二肽基肽酶IV 檢測試劑盒，*，現貨供應！

The DPPIV Drug Discovery Kit is a complete assay system designed to screen DPPIV inhibitors, providing enough material to perform at least 96 assays. DPPIV (DPP4, CD26) is a member of the class of proteases known as prolyl peptidases, which cleave proteins after proline residues and is thought to play roles in diabetes, cancer, and autoimmune diseases, making it a target for drug discovery.

The kit contains both a chromogenic substrate (H-Gly-Pro-pNA; K_m=114 µM) and a fluorogenic substrate (H-Gly-Pro-AMC; K_m=50 µM).

Cleavage of the p-nitroaniline (pNA) from the colorimetric substrate increases absorbance at 405 nm. The fluorimetric assay is based on the cleavage of 7-amino-4-methylcoumarin (AMC) moiety from the C-terminus of the peptide substrate, which increases its fluorescence intensity at 460 nm. The kit is useful to screen inhibitors of DPPIV, a potential therapeutic target. A DPPIV inhibitor, P32/98 (K_I=130 nM12), is included for use as a control. Other DPP enzymes are available for specificity profiling.

CD26檢測試劑盒

Product Specification

Alternative Name:	CD26 drug discovery kit, Dipeptidyl Peptidase IV drug discovery kit, DPP4 drug discovery kit

Long Term Storage:	-80°C

Kit/Set Contains:	DPPIV Enzyme (Human, recombinant) (Prod. No. BML-SE434-9090) (35 mU (40.4µl); 0.867 mU/µl. On U=1µmole/min@37°C, 100µM H-Gly-Pro-pNA. Purity ≥95% (SDS-Page)) Storage: -70°C; avoid freeze thaw cycles pNA substrate (Prod. No. BML-PI188-9090) (150µl; 10mM in DMSO) Storage: -70°C Calibration standard (p-nitroaniline) (Prod. No. BML-KI106) (1ml; 50µM in assay buffer) Storage: -70°C AMC Substrate (Prod. No. BML-P189-9090) (150µl; 0.5mM in DMSO) Storage: -70°C Calibration standard (7-Amino-4-methylcoumarin) (Prod. No. BML-KI107) (1ml; 40µM in assay buffer) Storage: -70°C) Inhibitor (Prod. No. BML-PI142-9090) (20µl; 1mM in DMSO) Storage: -70°C Assay Buffer (50mM TRIS, pH 7.5) (Prod. No. BML-KI342) (20ml; liquid in screw-cap plastic bottle) Storage: -20 or -70°C ?-volume clear microplate (Prod. No. BML-K101)Storage: Room temperature

相關文獻：

Product Literature References

16, 17-Dihydro-17b-hydroxy isomitraphylline alkaloid as an inhibitor of DPP-IV, and its effect on incretin hormone and β-cell proliferation in diabetic rat: A. Shukla, et al.; Eur. J. Pharm. 47, 512 (2012), Application(s): Measurement of inhibition of DPPIV by DHIM, Abstract;

Discovery and preclinical profile of Saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes: D. J. Augeri et al.; J. Med. Chem. 48, 5025 (2005), Abstract;

CD26/dipeptidyl peptidase IV and its role in cancer: B. et al.; Histol. Histopathol. 19, 1345 (2004), Abstract;

CD26/dipeptidyl peptidase IV: a regulator of immune function and a potential molecular target for therapy: U. Aytac et al.; Curr. Drug. Targets Immune Endocr. Metabol. Disord. 4, 11 (2004), Abstract;

Dipeptidyl peptidase IV inhibitors for the treatment of diabetes: A. E. Weber et al.; J. Med. Chem. 47, 4135 (2004),Abstract;

N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding: K. Aertgeerts et al.; Protein Sci. 13, 145 (2004), Abstract;

Dipeptidyl peptidase IV (CD26) activity in the hematopoietic system: differences between the membrane-anchored and the released enzyme activity: D. A. Pereira et al.; Braz. J. Med. Biol. Res. 36, 567 (2003), Abstract;

Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats: J. A. Pospisilik et al.; Diabetes 52, 741 (2003), Abstract;

Prolyl peptidases: a serine protease subfamily with high potential for drug discovery: J. S. Rosenblum et al.; Curr. Opin. Chem. Biol. 7, 496 (2003), Abstract;

Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV: R. Thoma et al.; Structure 11, 947 (2003), Abstract;

On the regulatory role of dipeptidyl peptidase IV (=CD=adenosine deaminase complexing protein) on adenosine deaminase activity: I. Ben-Shooshan; Biochim. Biophys. Acta. 1587, 21 (2002), Abstract;

Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties: H. Shibuya-Saruta; J. Clin. Lab. Anal. 10, 435 (1996), Abstract;

Activity of dipeptidyl peptidase IV and post-proline cleaving enzyme in sera from osteoporotic patients: H. Gotoh et al.; Clin. Chem. 34, 2499 (1988), Abstract;

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二肽基肽酶(dipeptidyl peptidase ，DPP)

二肽基肽酶(dipeptidyl peptidase ，DPP)是蛋白酶家族中的脯基肽酶成員，其可剪切含脯氨酸的蛋白，其中DPPIV (DPP4, CD26),是一種絲氨酸二肽基肽酶，其剪切靶多肽（細胞趨化因子如CXCL11和肽類激素如GLP-1）N端的X-Ala or X-Pro基. CD26是一種高度保守、分布于多種細胞的，具有跨膜域和很短的胞質域，但常被剪切和釋放作為可溶性環化4型，常形成自身二聚體或與FAP形成異二聚體。DPPⅣ的天然底物多種多樣，在體內執行多種重要功能。它還是細胞膜受體和共刺激分子，從而參與機體的免疫調節、細胞移行、細胞黏附和細胞調亡過程，故與多種疾病的發病有關。各種DPP-IV抑制劑對II型糖尿病、自身免疫性疾病及細胞增殖性疾病（腫瘤）的治療具有重要意義。DPP-4是重要的藥物開發靶點，其中DPP-IV抑制劑Januvia磷酸西他列汀Sitagliptin phosphate已作為抗糖尿病藥物上市。

DPP相關產品：（biomol）

Catalog #	Name	Category	size
AK-499	DPPIV Drug Discovery Kit	DPP Assay Systems	96T
SE-527	DPP8 (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-528	DPP9 (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-564	DPPII/DPP7 (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-529	DPPIII (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-434	DPPIV (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-409	FAP (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
SE-545	POP/PREP (human, recombinant)	DPP Enzymes and Assay Systems ? Prolyl Peptidase Enzymes and Assay Systems	10 µg
P188-0025	GP-pNA, Chromogenic Substrate	DPP 底物	25mg
P189-0005	GP-AMC, Fluorogenic Substrate 2	DPP 底物	5mg
SA451-0100	Anti-DPPIV	DDP抗體	100 µg
SA-472	Anti-FAPα	DDP抗體	100 µg
SE479-0100	Cystatin C	DPP Inhibitors抑制劑	100 µg
EI300-0001 EI300-0005	GM6001	DPP Inhibitors抑制劑	1 mg 5 mg
PI142-0010 PI142-0050	P32/98	DPP Inhibitors抑制劑	10 mg 50 mg
PI112-0005 PI112-0025	Z-Prolyl-prolinal	DPP Inhibitors抑制劑	5 mg 25 mg
EI106-0010 EI106-0050	Baicalein	DPP Inhibitors抑制劑	10 mg 50 mg

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