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英文名稱 Anti-AADAC/FITC
中文名稱 FITC標記的芳香乙酰胺脫乙酰基酶抗體
別 名 AAAD_HUMAN; Aada; Aadac; Arylacetamide deacetylase (esterase); Arylacetamide deacetylase; CES5A1; DAC.
說 明 書 100ug
研究領域 腫瘤 細胞生物 信號轉導
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, Sheep,
產品應用 ICC=1:50-200 IF=1:50-200
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 46kDa
細胞定位 細胞膜
性 狀 Lyophilized or Liquid
濃 度 2mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human AADAC (228-273aa)
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 Preservative: 15mM Sodium Azide, Constituents: 1% BSA, 0.01M PBS, pH 7.4
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
產品介紹 background:
The assembly of very-low-density lipoproteins (VLDLs) in the secretory apparatus of the hepatocyte relies on the mobilization of triacylglycerol (TAG) from the cytosolic pool by lipolysis and re-esterification. However, some of the re-esterified TAG products are returned to the cytosolic pool in the liver, which protects vulnerable body tissues from excess lipotoxic non-esterified fatty acids in the plasma. Some of the lipases involved in this process include arylacetamide deacetylase (AADAC) and its related proteins AADACL1 and AADACL2. AADAC, a single pass type II membrane protein of the endoplasmic reticulum, is expressed in hepatocytes, intestinal mucosal cells, pancreas and adrenal gland. It plays an important role in the metabolic activation of arylamine substrates to ultimate carcinogens. AADACL1 hydrolyzes the metabolic intermediate 2-acetyl monoalkylglycerol, and its inactivation results in disruption of ether lipid metabolism in cancer cells and impaired cell migration and tumor growth.
Function:
Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores.
Subcellular Location:
Endoplasmic reticulum membrane. Microsome membrane.
Tissue Specificity:
Mainly expressed in liver, small intestine, colon and adrenal gland.
Similarity:
Belongs to the 'GDXG' lipolytic enzyme family.
Database links:
UniProtKB/Swiss-Prot: P22760.5
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
南京森貝伽生物科技有限公司，http://www.senbeijia.com/（NanJing SenBeiJia Biotechnology Co.,LTD.）成立于2012年，位于江寧大學城，是一家立足于生命科學領域有自主知識產權的國家*，公司現有員工40余人，產品涵蓋分子生物學、蛋白質組學、免疫學、細胞生物學等研究和應用領域。
主營產品：
擁有發明的自主研發ELISA試劑盒，經驗豐富，質量過硬。
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公司擁有*的儀器設備和一批海歸博士、碩士研究人員，并在清華大學建有自己的實驗室與研發基地，為生命科學客戶提供實驗技術服務，如酶聯免疫ELISA、Western Blot、免疫組化（包埋，切片，HE）、Realtime PCR、流式細胞檢測等。
企業宗旨是：提供*質的產品和服務，做有影響力的生物技術公司
在21世紀生命科學迅猛發展的時代，南京森貝伽生物科技有限公司在我們全體員工的不懈努力下，以Z快速、Z高質量、較好的態度，為客戶提供一個穩定平臺，為客戶提供優質的服務，成為客戶可信賴的*合作的伙伴，相信在未來的工作中，南京森貝伽一定能夠成為您得力的助手和值得信賴的合作伙伴！
ELISA試劑盒，免疫組化，蛋白組學，細胞生物，標準品，生化試劑，實驗耗材
FITC標記的芳香乙酰胺脫乙酰基酶抗體 產品信息
