| Catalogue Number | CYT-634 | ||||
| Patent Protected Countries | The Sale of recombinant Mouse IL-18 by ProSpec is prohibited in the following countries: United States, Japan, United Kingdom, France, Spain, Italy, Germany, Austria, Belgium, Denmark, Portugal, Sweden, Switzerland, Liechtenstein, Australia, Taiwan, Netherlands, Korea and Canada. | ||||
| Synonyms | Interferon-gamma-inducing factor, IGIF, IL-1g, IL-18, IL1F4, MGC12320, IFN-gamma-inducing factor, Interleukin-1 gamma, IL-1 gamma, Iboctadekin, Il18. | ||||
| Introduction | IL-18 is a proinflammatory cytokine. This cytokine can induce the IFN-gamma production of T cells. The combination of this cytokine and IL12 has been shown to inhibit IL4 dependent IgE and IgG1 production, and enhance IgG2a production of B cells. IL-18 binding protein （IL18BP） can specifically interact with this cytokine, and thus negatively regulate its biological activity. | ||||
| Description | Interleukin-18 Mouse Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 178 amino acids （36-192 a.a.） and having a molecular mass of 20.4 kDa. The Mouse IL-18 is fused to 20 amino acids His Tag at N-terminus and purified by proprietary chromatographic techniques. | ||||
| Source | Escherichia Coli. | ||||
| Physical Appearance | Sterile Filtered colorless liquid formulation. | ||||
| Formulation | The Mouse IL-18 protein solution contains 20mM Tris-HCl pH-8 and 10% glycerol. | ||||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. Please avoid freeze thaw cycles. | ||||
| Purity | Greater than 90.0% as determined by SDS-PAGE. | ||||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MNFGRLHCTT AVIRNINDQV LFVDKRQPVF EDMTDIDQSA SEPQTRLIIY MYKDSEVRGL AVTLSVKDSK MSTLSCKNKI ISFEEMDPPE NIDDIQSDLI FFQKRVPGHN KMEFESSLYE GHFLACQKED DAFKLILKKK DENGDKSVMF TLTNLHQS. | ||||
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||
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