| Catalogue Number | CYT-691 | ||||||
| Synonyms | GDF-15, MIC1, MIC-1, NAG-1, PDF, PLAB, PTGFB, Growth/differentiation factor 15, Placental bone morphogenetic protein, Placental TGF-beta, Macrophage inhibitory cytokine 1, Prostate differentiation factor, NSAID-activated gene 1 protein, NSAID-regulated gene 1 protein, NRG-1, GDF15. | ||||||
| Introduction | GDF15 is part of the TGF-Beta superfamily that is involved in regulating inflammatory and apoptotic pathways in injured tissues and throughout disease processes. GDF15 is most abundant in the liver. Its expression in liver can be considerably up-regulated in during injury of organs such as liver, kidney, heart and lung. GDF-15 promotes proliferation or growth arrest and differentiation due to differences in cellular differentiation. GDF15 prevents apoptosis in cerebellar granule neurons by activating Akt and inhibiting endogenously active ERK. GDF15 is a novel autocrine/endocrine factor that antagonizes the hypertrophic response and loss of ventricular performance. | ||||||
| Description | Recombinant Human GDF15 produced in E.Coli is a single, non-glycosylated polypeptide chain containing 151 amino acids （195-308） and having a molecular mass of 16.7 kDa（molecular weight on SDS-PAGE will appear higher）. GDF15 is expressed with a 36 amino acid His tag fused at N-Terminus and purified by proprietary chromatographic techniques. | ||||||
| Source | Escherichia Coli. | ||||||
| Physical Appearance | Sterile filtered colorless solution. | ||||||
| Formulation | The GDF15 protein solution contains 10mM sodium citrate, pH-3.5 & 10% glycerol. | ||||||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein （0.1% HSA or BSA）. Avoid multiple freeze-thaw cycles. | ||||||
| Purity | Greater than 95.0% as determined by SDS-PAGE. | ||||||
| Amino Acid Sequence | MRGSHHHHHH GMASMTGG MGRDLYDDDD KDRWGSMARA RNGDHCPLGP GRCCRLHTVR ASLEDLGWAD WVLSPREVQV TMCIGACPSQ FRAANMHAQI KTSLHRLKPD TVPAPCCVPA SYNPMVLIQK TDTGVSLQTY DDLLAKDCHC I. | ||||||
| Usage | ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals. | ||||||
| Related Products |
|
上海高創化學科技有限公司，是一家專注于生命科學和生物技術領域的高科技企業，是國內代理銷售生物試劑、儀器的公司之一。公司本著為顧客服務、為科研服務的宗旨，為中國的專家和學者提供種類齊全的高品質產品。高創公司已與多家歐美*生物技術公司簽訂*或區域代理協議，銷售的實驗儀器、消耗品、分子生化試劑、免疫試劑和細胞培養試劑等，已被廣泛應用于生命科學基礎研究、開發應用、制藥、疾病診斷與控制、人口與健康、生物技術等諸多領域?？蛻舯椴即髮W、研究所、醫院、衛生防疫、商品檢驗檢疫、制藥公司、生物技術公司和食品工業等單位。主要產品包括：英國Randox-lifesciences公司的藥物殘留ELISA試劑盒、抗體抗體蛋白；挪威Biosese公司的檢測表面活性劑、農藥殘留、毒素、PCB等相關有害物質的ELISA檢測試劑盒以及魚類蛋白和抗體；Gibco公司DMEM培養基、1640培養基、F12培養基，MEM培養基、F10培養基等；Prospec-Tany公司的細胞因子、生長因子、蛋白激酶、重組和天然蛋白、酶以及病毒抗原和抗體；美國eBioscience公司的流式細胞術產品等。
高創的宗旨是：為用戶提供“Z高質量的產品” 和 “*質的服務”。
ELISA試劑盒，細胞因子，重組蛋白，抗原，抗體，生化試劑，分子生物學試劑
重組人生長分化因子15,Human GDF15 產品信息
