mach-1典型功能介紹
- 拉壓扭剪切摩擦穿刺多功能測試
- 不規則表面自動壓痕厚度mapping→
- 3D輪廓測量(三維表面微觀形貌表征)→
- 軟骨質量功能流動電位評估
- 摩擦磨損剪切模量測試
- 塔接結合力粘合力
- 力&電偶聯測試分析
- 動態機械特性測試分析
- DIC非接觸式quan場應變動態測量
- 側限壓縮(confined compression)
- 耐滲透性測試
生物力學相關其他產品
- biotester生物材料雙軸測試系統
- MicroSquisher多種微力測試分析系統
- UniVert單軸拉伸、壓縮和扭力測試分析
- Flexcell細胞拉壓流體剪切培養儀
- 單層細胞壓力加載培養與實時觀察分析系統
- TGT三維血管軟骨皮膚應力培養系統
- 血管生物反應器
- 肌腱韌帶生物反應器
- 軟骨生物反應器
- 旋轉灌流生物反應器
- 骨組織灌流表型生物反應器
- 皮膚生物反應器
- 凝膠支架種子細胞構建生物組織系統
- 皮膚彈性測試分析儀
- ITI單層細胞靜水壓力培養系統
- 細胞牽引力顯微鏡
- 細胞組織力學特性定量分析光鑷
- 離體或活體在體骨參考點壓痕測量分析儀
- 高通量細胞力學特性分析流式細胞儀
- 血管血流循環模擬系統
- VCU顱腦損傷儀
- 三維微流控芯片系統
- 更多
biomomentum Mach-1 生物力學形變數字散斑相關法測試分析系統,生物力學變形DIC分析系統，生物力學DIC分析儀，DIC三維場應變測量，DIC三維變形測量，生物力學變形過程中斑點圖案樣本的變形，位移，應變和光流測試分析系統
biomomentum Mach-1多功能生物力學測試系統
該系統是一種高分辨率的微機械特性測試系統，可用于評估各種應用中生物組織和生物材料的機械性能。
它能做什么？
●以各種模式進行壓縮和拉伸測試，包括：動態，靜態，應力松弛，蠕變，波形加載
●高精度測試，小位移精度
●適合標準的組織培養箱
行程范圍：250毫米
重現性0.01μm
雙向重復精度±0.1μm
大速度50 mm / s
小速度0.1μm/ s
負載能力：0.0025mN --- 250N
該系統使用跟蹤和圖像配準技術對樣品在變形過程中的變化進行j確的2D和3D測量。 這通常用于測量變形過程中斑點圖案樣本的變形，位移，應變和光流。
該系統數字圖像關聯（DIC）
數字圖像相關（Digital Image Correlation,DIC）也就是數字圖像相關方法是一種非接觸式的高精度位移、應變測量方法，是目前實驗力學領域內有應用前景的測量方法。 測量quan場應變廣泛應用于組織材料力學、斷裂力學、微觀納米應變測量、各種新型材料測量等。該測量具有非接觸性、應用廣泛、精度較高、quan場測量、 數據采集簡單、測量環境要求不高、易于實現自動化等優點，可以測量微米甚至納米的變形。 是一種對材料或者結構表面在外載荷或其他因素作用下進行場位移和應變分析的新的實驗力學方法。目前DIC技術已經在電子封裝、材料測試、斷裂力學、航空航天、生物力學以及顯微測量等眾多領域得到應用，取得了矚目的成就
典型文獻：
Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and Sliding
Hsu FH, Hui AY, Chen AC, Lotz MK and Sah R
Orthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256
Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates to microscale tissue deformation have been assessed in vitro to range from 2.8 to 41.0% depending on the tissue state and lubrication 4 . Biologically, dynamic shear at small amplitudes (±3%) markedly stimulates PRG4 secretion by immature bovine cartilage disks, but little evidence has been provided for similar effects in human cartilage, perhaps due to insufficiently large amplitudes of stimulation 5 . A prior study on the effects of torsional shear on chondrocyte apoptosis has suggested that superficial zone (SZ) cell apoptosis occurs in bovine explants when sheared without lubrication 6 . However, it is unknown whether (1) the degree of SZ cell death and amount of PRG4 secretion is a function of shear and sliding amplitudes and (2) how much resultant tissue deformation and sliding occurs during the chosen method of shear. Therefore, the hypothesis for this study was that articulation induces an amplitude-dependent effect on cartilage superficial zone health and responses, and that the variations in responses are due in part to the extent of tissue shear. Thus, the aims were to assess the effects of graded levels of articulation on chondrocyte viability and PRG4 secretion, and to relate these biological responses to the level of tissue shear.
Methods: A total of 25 human articular cartilage disks (2mm diameter, 1.1mm thick) were harvested from the patellofemoral groove of each of 9 cadaveric knees of donors spanning a wide age range [n=3 Young (<30 yrs), 19, 26 and 29 yrs; n=6 Old (>50yrs), 51, 54, 55, 61, 64, and 66 yrs] without evidence of osteoarthritis; the samples were prepared to include the articular surface, and from regions of tissue with a macroscopically intact articular surface. Disks were incubated in medium supplemented with 10% FBS and 25 ?g/ml ascorbate. On day 3-5, some disks were subjected to mechanical articulation at Low, Mid, or High amplitudes, and others left free-swelling (None). Immediately after treatment, some disks were analyzed for chondrocyte viability at the articular surface. Other disks were incubated for two additional days to assess effects of Low and High articulation on subsequent PRG4 secretion. Some of the donor-matched disks were analyzed mechanically to assess the effects of Mid and High articulation on shear strain and shear stress. Mechanical stimulation. Articulation was implemented at sliding amplitudes of ±100?m, ±500?m, or ±1000?m using a sinusoidal 1Hz waveform in order to simulate effects of Low, Mid, or High levels, respectively. The articulation was imposed for 400 cycles and superimposed upon 20% static compression using a Mach-1 mechanical tester (Biomomentum) with a surface-finished polysulfone platen for articulation against the articular surface 7 and a roughened surface and trough to stabilize the deep cartilage surface. Multi-axial load was recorded. Other disks were maintained free-swelling (None) to serve as control. SZ cell viability analysis. Disks were stained with Live/Dead® (Invitrogen) immediately after treatment, and en face images of the disks were taken at 10x magnification with a fluorescent microscope. The resulting live and dead images were analyzed using a custom image-processing program to determine the number and percentages of live and dead cells. PRG4 protein secretion.. Conditioned medium, collected during the two days of incubation after articulation, was analyzed for PRG4 by ELISA. Biomechanical analysis of tissue shear. The response of cartilage disks was then assessed by video analysis. Videos were recorded with a Nikon D90 SLR digital camera, fitted with a macro lens, and frames analyzed for disk and platen position to determine shear deformation during imposed articulation. Statistics. Summary statistics are presented as mean ± SEM, with n = # of cartilage disks per experimental condition per donor knee, and m = # of donors, so that n*m = total cartilage disks per condition. Data that ranged over an order of magnitude were log10 (1+Y) transformed and percentage data were arc sine transformed prior to statistical analyses to improve normality and homoscedasticity. The effects of mechanical treatment on SZ cell death was assessed by 1-way ANOVA and post-hoc Tukey test. Linear regression of both maximum shear stress and strain to cell death were performed. The effects of age and mechanical stimulus on cartilage PRG4 secretion were assessed by 2-way ANOVA with donor as a random factor.
Results: Articulation induced chondrocyte death in the superficial zone in an amplitude-dependent manner (Fig. 1). In control samples and those subjected to Low articulation, SZ cell viability was high at 90-95%. Mid and high amplitudes of applied articulation resulted in a reduction of viability by 20-25% (p<0.01). Cartilage PRG4 secretion was modulated by age group (p <0.001) and articulation stimulus (p<0.001) in an interactive manner (p<0.01, Fig. 2). In the absence of applied mechanical stimulation, PRG4 secretion by cartilage from young donors was higher (+4.7 ?g/(cm2?day), p<0.05) than that of old donors. With mechanical stimulation, higher articulation resulted in higher PRG4 secretion (+4.0 and +6.8 ?g/(cm2?day), respectively, for low and high articulation) in young donors, but did not have a discernible effect on cartilage from old donors (-0.04 and -0.4 ?g/(cm2?day), for low and high shear, respectively). Cell death and cartilage PRG4 secretion responses were associated with donor-specific tissue mechanics ( Fig. 3 ). Positively correlations were found between cell death and shear stress (Fig. 3A & C, p<0.05) as well as PRG4 secretion and shear strain (p<0.05). Trends were observed between cell death and high shear strain, but were not significant (Fig.3B, p=0.10).
Discussion: The finding that high levels of cartilage shear stress and/or strain can lead to cell death suggests the susceptibility of cartilage to states when lubrication is deficient and/or tissue asperities lead to high articulation-induced tissue shear. On the other hand, the stimulated PRG4 secretion response suggests that the remaining cells can exhibit a feedback response, attempting to counter the excessive shear, as suggested previously 5 . The correlation of biological effects with tissue-specific biomechanical properties suggests that age-related variations in human articular cartilage properties could be involved in variations in mechanobiology. The lack of mechanical responsiveness of human articular cartilage with aging may contribute to the increased incidence of osteoarthritis with aging.
Significance: The susceptibility of articular cartilage to shear-induced cell death suggests that mechanical protection strategies may be helpful to prevent subsequent development of osteoarthritis. Further understanding of the mechanobiological alteration of human cartilage with aging may involve both mechanical properties of the tissue matrix as well as biological variations in the chondrocytes.
Mach-1 Analysis Software - Add-On for Indentation Testing (Elastic Model) MA725 Add an analytic module for spherical indentation 
Mach-1 Analysis Software - Add-On for Unconfined & Confined Compression (Poroelastic) MA726 Add an analytic model to fit unconfined compression data to a poroelastic model 
Mach-1 Motion Software - Add-On for Normal Indentation MA724 Activates the Normal Indentation Function 
Mach-1 Motion Software - Add-On for Camera Feed MA723 Add a live camera feed in the Mach-1 Motion software 
Mach-1 Motion Software - Add-On for Analog Inputs MA722 Adds analog inputs to the tester 
Mach-1 Motion Software - Add-On for Mutiple-Axis Load Cell MA721 This software add-on is required to activate multiaxial load cell 
Mapping Toolbox MT337 A software to handle cartographic characterization data 
Microsoft Office License MA620 Word, Excel, PowerPoint, OneNote 
Color Camera (1.3MPx) with Lens (12.5mm) and Support MA732 Camera used to image the sample Literature ()
Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride Introduction: Cartilage degeneration is a progressive process and currently, only end-stage surgical treatments such as total knee replacement (TKR) lead to an improved condition. To prevent or delay this surgery, several less invasive alternatives could be considered, such as pharmacological treatments, scaffolds and partial replacements1. However, current diagnostic techniques are limited...Read More Guided subchondral bone marrow stimulation through a novel biomaterial microparticle approachHoemann C, Guzman-Morales J, Chen G, Picard G, Veilleux D, Sim S, Garon M, Quenneville E, Buschmann MD, Lafantaisie-Favreau CH and Hurtig MPresentation #335.2 on Fri May 20 from 16:30 to 18:15 in Room 516C at World Congress on Biomechanics, Montreal, May 2016 Hyaline-like cartilage repair can be occasionally elicited by bone marrow stimulation procedures however mainly in younger patients, indicating the need for further treatments to improve success rates in middle-aged patients. Traditional scaffold-guided repair approaches use a solid material to fill the wound void and to provide a mechanically stable substrate for cell attachment, ingrowth and differentiation....Read More Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256 Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014. A major risk factor for knee osteoarthritis (OA) is meniscal injury or excision. Surgeons now advocate for meniscal repair or allografts rather than excision with this knowledge in hand. Clinical assessment of the meniscal load sharing is limited to meniscus position by MRI, so the efficacy of replacement and repair must be done in cadaveric knees. In the past, pressure sensitive film and mechanical...Read More Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritis Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CE2015 International Cartilage Repair Society, May 7-11 2015, Chicago, Illinois, USA. Podium presentation (ID: 23.2.9) Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain (STR/ort)...Read More Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using Indentation (OARSI Poster)Lavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain...Read More Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis and Cartilage 23 Suppl. 2, p. A254 (2015) Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain (STR/ort)...Read More Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France. Purpose: An important measure of articular cartilage function in health and disease is its biomechanical properties. While much research has mouse models of osteoarthritis, the assessment of biomechanical properties in these small joints is quite challenging. We have previously developed novel and easily implemented indentation technique on sheep stifle joints and rat knee joints. The purpose...Read More Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229 Introduction: A currently unsatisfied need in Arthritis and cartilage research is to assess the function of the entire articular cartilage surface both quantitatively and non-destructively. The objective of this study was to investigate the ability of a novel automatic technique to characterize mechanical properties of entire articular surfaces in indentation in order to rapidly discriminate...Read More Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4) Introduction: The identification and quantitative grading of early degenerated regions over an entire articular surface remains a challenging quest. The objective of this study was to investigate the ability of a novel technique to automatically characterize mechanical properties of entire human articular surfaces in indentation in order to rapidly and non-destructively discriminate between...Read More Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359 Introduction: In cartilage regeneration and repair, mechanical testing of articular cartilage characterizes functional restoration of the repair site [1] and can detect early degeneration of articular cartilage [2]. However, the experimental design often incorporates the use of cartilage adjacent to the treated site or at contralateral sites as normal references to evaluate the effect of treatment...Read More Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada Introduction: Mechanical characterization of wound healing in skin samples mostly relies on uniaxial tensile rupture tests, which provide local information along the wound and are disruptive for samples (Chao et al., 2011). In this study, we wanted to test the ability of a novel automated indentation technique to non-destructively characterize mechanical properties of the entire wound and its...Read More Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016 In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain The purpose of this study was to evaluate the capability of an automated indentation technique to reveal the topographical variation of mechanical properties over the entire articular surface of the temporomandibular joint (TMJ), especially the thickness and instantaneous modulus (IM). Mechanical properties of visually normal temporal bones and condyles of a porcine TMJ were mapped ex vivo using a...Read More Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014 Introduction: Histological scoring, biochemical analyses and biomechanical testing (unconfined compression) are often seen as gold standard characterizations for articular cartilage but can present major drawbacks in the context of animal and human studies where characterization of complete intact articular cartilage surfaces is required. In particular, histology, biochemical and mechanical...Read More Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015 Introduction: It is challenging to identify and grade degenerated regions of the entire articular surface both quantitatively and non-destructively. Therefore, the objective of this study was to investigate the ability of a novel technique to automatically characterize mechanical properties of entire articular surfaces in indentation to rapidly discriminate between damaged articular cartilage...Read More Evaluation of a novel technique to map the mechanical properties of an entire articular surface in indentationSim S, Quenneville E, Garon M, Hoemann CD, Hurtig M and Buschmann MDInternational Cartilage Repair Society (ICRS), Turkey, 2013, Podium presentation (11.2.9) Purpose: Mechanical testing of articular cartilage is recommended by the FDA for products intended for the repair or replacement of knee cartilage. One experimental configuration that has many practical advantages is indentation. However, one limitation is the need to perpendicularly position the articular surface to the indenter. The objective of this study was to investigate the ability of...Read More Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014 (In Germany only) In der Materialprüfung sind Indentationsverfahren bereits seit Jahren g?ngige Praxis. Jedoch war es bisher nicht so ohne weiteres m?glich Gewebeproben, insbesondere Weichgewebe wie Knorpel zu untersuchen. Mit dem Mikroindenter Mach-1TM von Biomomentum k?nnen sowohl flexible Biomaterialien wie Kontaktlinsen oder Wundauflagen aus elektrogesponnenen Gelatinefliesen genauso wie biologische...Read More ASTM D5656 - Standard Test Method for Thick-Adherend Metal Lap-Shear Joints for Determination of the Stress-Strain Behavior of Adhesives in Shear by Tension LoadingASTM International, West Conshohocken, PA, 2010, Significance and Use
This test method can be used to determine the stress-strain properties of an adhesive in shear and to establish the proportional-limit of the stress-stain relationship. This data may be useful for the design and analysis of adhesively bonded joints.
This test method is not intended to determine adhesion characteristics of an adhesive to a particular substrate;...Read More ASTM D5748 - Standard Test Method for Protrusion Puncture Resistance of Stretch Wrap FilmASTM International, West Conshohocken, PA, 2012, Significance and Use
Puncture resistance is very important in end-use performance of stretch wrap film used in consumer and industrial product applications. Puncture resistance is a measure of the energy-absorbing ability of a stretch wrap film in resisting a protrusion. The test method is designed to provide the user with a means of measuring the stretch wrap film's puncture...Read More ASTM D575 - Standard Test Methods for Rubber Properties in CompressionASTM International, West Conshohocken, PA, 2012, Significance and Use
These test methods are useful in comparing stiffness of rubber materials in compression. They can be used by rubber technologists to aid in development of materials for compressive applications.
Scope
1.1 These test methods cover two test procedures for determining the compression-deflection characteristics...Read More ASTM D6195 - Standard Test Methods for Loop TackASTM International, West Conshohocken, PA, 2011, Significance and Use
These test methods provide a quantitative measure of the pressure-sensitive tack property of an adhesive.
These test methods are designed to measure the tack property of the adhesive mass. The tack of a given adhesive varies depending on the backing (generally, stiffer backings lead to higher values).
Theses test methods are suitable for quality control...Read More ASTM D624 - Standard Test Method for Tear Strength of Conventional Vulcanized Rubber and Thermoplastic ElastomersASTM International, West Conshohocken, PA, 2012, Significance and Use
Vulcanized rubber and thermoplastic elastomers (TPE) often fail in service due to the generation and propagation of a special type of rupture called a tear. This test method measures the resistance to tearing action.
Tear strength may be influenced to a large degree by stress-induced anisotropy (mechanical fibering), stress distribution, strain rate, and...Read More ASTM D638 - Standard Test Method for Tensile Properties of PlasticsASTM International, West Conshohocken, PA, 2014, Significance and Use
4.1 This test method is designed to produce tensile property data for the control and specification of plastic materials. These data are also useful for qualitative characterization and for research and development.
4.2 Some material specifications that require the use of this test method, but with some procedural modifications that take precedence when...Read More ASTM F1306 - Standard Test Method for Slow Rate Penetration Resistance of Flexible Barrier Films and LaminatesASTM International, West Conshohocken, PA, 2016, Significance and Use
4.1 Penetration resistance is an important end-use performance of thin flexible materials where a sharp-edged product can destroy the integrity of a barrier wrap. This will permit package entry/exit of gases, odors, and unwanted contaminates, causing potential harm to the product and reducing shelf-life. Material response to penetration will vary with numerous...Read More ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009, Abstract
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More ASTM F1717 - Standard Test Methods for Spinal Implant Constructs in a Vertebrectomy ModelASTM International, West Conshohocken, PA, 2015, Significance and Use
5.1 Spinal implants are generally composed of several components which, when connected together, form a spinal implant assembly. Spinal implant assemblies are designed to provide some stability to the spine while arthrodesis takes place. These test methods outline standard materials and methods for the evaluation of different spinal implant assemblies so...Read More ASTM F88-M - Standard Test Method for Seal Strength of Flexible Barrier MaterialsASTM International, West Conshohocken, PA, 2015, Significance and Use
4.1 Seal strength is a quantitative measure for use in process validation, process control, and capability. Seal strength is not only relevant to opening force and package integrity, but to measuring the packaging processes' ability to produce consistent seals. Seal strength at some minimum level is a necessary package requirement, and at times it is...Read More ASTM D2979 - Standard Test Method for Pressure-Sensitive Tack of Adhesives Using an Inverted Probe MachineASTM International, West Conshohocken, PA, 2016, Significance and Use
This test method provides a quantitative measure of the pressure-sensitive tack of the adhesive. The method is designed for the adhesive mass itself and is suitable for measuring the tack of pressure-sensitive adhesives for use on both rigid and flexible backings. This test method is suitable for quality control and research purposes. <>Read More Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428 Introduction: During joint articulation, cartilage, particularly that near the articular surface, undergoes a complex combination of compression, shear, and sliding.1,2 In vitro analyses have focused on cartilage biomechanics in response to relative surface movement at a constant velocity after startup. However, joint movement typically involves variability in the relative surface velocity....Read More FAQs (1)
Mach-1 Analysis Software - Add-On for Indentation Testing (Elastic Model)
MA725
Add an analytic module for spherical indentation
Mach-1 Analysis Software - Add-On for Unconfined & Confined Compression (Poroelastic)
MA726
Add an analytic model to fit unconfined compression data to a poroelastic model
Mach-1 Motion Software - Add-On for Normal Indentation
MA724
Activates the Normal Indentation Function
Mach-1 Motion Software - Add-On for Camera Feed
MA723
Add a live camera feed in the Mach-1 Motion software
Mach-1 Motion Software - Add-On for Analog Inputs
MA722
Adds analog inputs to the tester
Mach-1 Motion Software - Add-On for Mutiple-Axis Load Cell
MA721
This software add-on is required to activate multiaxial load cell
Mapping Toolbox
MT337
A software to handle cartographic characterization data
Microsoft Office License
MA620
Word, Excel, PowerPoint, OneNote
Color Camera (1.3MPx) with Lens (12.5mm) and Support
MA732
Camera used to image the sample
Literature ()
Assessment of Human Articular Cartilage Issued from Asymptomatic & TKR DonorsHadjab I, Sim S, Quenneville E, Garon M and Buschmann MDBiomedical Engineering Society 2015 in Tampa, Floride
Introduction: Cartilage degeneration is a progressive process and currently, only end-stage surgical treatments such as total knee replacement (TKR) lead to an improved condition. To prevent or delay this surgery, several less invasive alternatives could be considered, such as pharmacological treatments, scaffolds and partial replacements1. However, current diagnostic techniques are limited...Read More
Guided subchondral bone marrow stimulation through a novel biomaterial microparticle approachHoemann C, Guzman-Morales J, Chen G, Picard G, Veilleux D, Sim S, Garon M, Quenneville E, Buschmann MD, Lafantaisie-Favreau CH and Hurtig MPresentation #335.2 on Fri May 20 from 16:30 to 18:15 in Room 516C at World Congress on Biomechanics, Montreal, May 2016
Hyaline-like cartilage repair can be occasionally elicited by bone marrow stimulation procedures however mainly in younger patients, indicating the need for further treatments to improve success rates in middle-aged patients. Traditional scaffold-guided repair approaches use a solid material to fill the wound void and to provide a mechanically stable substrate for cell attachment, ingrowth and differentiation....Read More
Articulation-Induced Responses of Superficial Zone Chondrocytes in Human Knee Articular Cartilage - Effects of Shear and SlidingHsu FH, Hui AY, Chen AC, Lotz MK and Sah ROrthopeadic Research Society Annual Meeting in Las Vegas, Abstract 0256
Introduction: During daily physical activities, joint articulation results in 3-10% compression in its overall thickness. There is also consensus that articulation is a combined process of shearing and sliding, with relative rotational and translational motions between femoral condyle and tibia cartilage at least at the millimeter scale 2,3. The macroscale motions in the joint which translates...Read More
Micro-CT visualization and indentation properties of whole meniscus following mercury exposureKolaczek S, Changoor A, Hurtig M, Gordon K and Getgood AAnnual Meeting of the ORS, New Orleans, Louisiana, USA, March 15-18, 2014.
A major risk factor for knee osteoarthritis (OA) is meniscal injury or excision. Surgeons now advocate for meniscal repair or allografts rather than excision with this knowledge in hand. Clinical assessment of the meniscal load sharing is limited to meniscus position by MRI, so the efficacy of replacement and repair must be done in cadaveric knees. In the past, pressure sensitive film and mechanical...Read More
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritis Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CE2015 International Cartilage Repair Society, May 7-11 2015, Chicago, Illinois, USA. Podium presentation (ID: 23.2.9)
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain (STR/ort)...Read More
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using Indentation (OARSI Poster)Lavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis Research Society International (OARSI), 2015 April 30, Seattle, WA, United States
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain...Read More
Mapping Articular Cartilage Biomechanical Properties of Normal and Osteoarthritic Mice Using IndentationLavoie JF, Sim S, Quenneville E, Garon M, Moreau A, Buschmann MD and Aubin CEOsteoarthritis and Cartilage 23 Suppl. 2, p. A254 (2015)
Purpose: Due to their size (~1mm), mouse models pose significant challenges to map biomechanical properties over their articular surfaces. The purpose of this study was to determine if an automated indentation technique could be used to map the biomechanical properties of the articular surfaces in murine knees and to identify early alterations of the articular cartilage of a mouse strain (STR/ort)...Read More
Novel Technique to Map the Biomechanical Properties of Entire Mice Articular Surfaces Using IndentationSim S, Lavoie JF, Moreau A, Quenneville E, Garon M, and Buschmann MDOsteoarthritis and Cartilage, 22(1), 541. World Congress on Osteoarthritis, April 2014, Paris, France.
Purpose: An important measure of articular cartilage function in health and disease is its biomechanical properties. While much research has mouse models of osteoarthritis, the assessment of biomechanical properties in these small joints is quite challenging. We have previously developed novel and easily implemented indentation technique on sheep stifle joints and rat knee joints. The purpose...Read More
Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Degenerated (Osteoarthritis-like) CartilageSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD7th World Congress on Biomechanics, 2014, Boston, MA, USA. Poster 2229
Introduction: A currently unsatisfied need in Arthritis and cartilage research is to assess the function of the entire articular cartilage surface both quantitatively and non-destructively. The objective of this study was to investigate the ability of a novel automatic technique to characterize mechanical properties of entire articular surfaces in indentation in order to rapidly discriminate...Read More
Indentation Method to Map Mechanical Properties of Articular Surface to Identify Degenerated RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MD2014 Annual Meeting of the Biomedical Engineering Society, 2014, San Antonio, TX, USA. Podium presentation (ID: OP-Sat-3-4)
Introduction: The identification and quantitative grading of early degenerated regions over an entire articular surface remains a challenging quest. The objective of this study was to investigate the ability of a novel technique to automatically characterize mechanical properties of entire human articular surfaces in indentation in order to rapidly and non-destructively discriminate between...Read More
Relevance of the Spatial Distribution of Mechanical Properties of Articular Cartilage in Animal StudiesSim S, Hadjab I, Garon M, Quenneville E, and Buschmann MDOrthopeadic Research Society Annual Meeting in Las Vegas, 2015, Poster 0359
Introduction: In cartilage regeneration and repair, mechanical testing of articular cartilage characterizes functional restoration of the repair site [1] and can detect early degeneration of articular cartilage [2]. However, the experimental design often incorporates the use of cartilage adjacent to the treated site or at contralateral sites as normal references to evaluate the effect of treatment...Read More
Wound Healing Revealed by a Novel Automated Indentation TechniqueSim S, Garon M, Quenneville E and Buschmann MDCanadian Connective Tissue Conference 2015 in Quebec, Canada
Introduction: Mechanical characterization of wound healing in skin samples mostly relies on uniaxial tensile rupture tests, which provide local information along the wound and are disruptive for samples (Chao et al., 2011). In this study, we wanted to test the ability of a novel automated indentation technique to non-destructively characterize mechanical properties of the entire wound and its...Read More
Development of a Sequence of Mechanical Tests for Articular Cartilage at a Single LocationSim S, Chartrａnd A, Lavallee AP, Tessier J, Garon M, Quenneville E and Buschmann MDOrthopeadic Research Society Annual Meeting in Orlando, 2016
In a recent study, our group has highlighted the importance of considering the natural topographic variability of the mechanical properties over the articular surface, particularly in the context of cartilage repair, where it can screen the effect of a treatment [1]. Moreover, the availability of test sample is limited in those repair studies since the regions of interest are often limited in size....Read More
Cartilage Stiffness and Thickness Distributions Revealed by an Automated Indentation Technique in the Temporomandibular JointSim S, Matuska A, Garon M, Quenneville E, McFetridge P and Buschmann MDTMJ Bioengineering Conference - V, September 12-13, 2016, Barcelona, Spain
The purpose of this study was to evaluate the capability of an automated indentation technique to reveal the topographical variation of mechanical properties over the entire articular surface of the temporomandibular joint (TMJ), especially the thickness and instantaneous modulus (IM). Mechanical properties of visually normal temporal bones and condyles of a porcine TMJ were mapped ex vivo using a...Read More
Correlation of Non-destructive Electromechanical Probe (Arthro-BST) Assessment with Histological Scores, Biochemical Composition and Mechanical Properties in Human Knee JointsSim S, Chevrier A, Quenneville E, Garon M and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, New Orleans, LA, USA, Poster 0439, 2014
Introduction: Histological scoring, biochemical analyses and biomechanical testing (unconfined compression) are often seen as gold standard characterizations for articular cartilage but can present major drawbacks in the context of animal and human studies where characterization of complete intact articular cartilage surfaces is required. In particular, histology, biochemical and mechanical...Read More
Novel Technique to Map the Biomechanical Properties of Entire Articular Surfaces Using Indentation to Identify Osteoarthritis-like RegionsSim S, Chevrier A, Garon M, Quenneville E and Buschmann MDTransactions of the 60th Annual Meeting of the Orthopaedic Research Society, 2014, New Orleans, LA, USA, 2015, Poster #2015
Introduction: It is challenging to identify and grade degenerated regions of the entire articular surface both quantitatively and non-destructively. Therefore, the objective of this study was to investigate the ability of a novel technique to automatically characterize mechanical properties of entire articular surfaces in indentation to rapidly discriminate between damaged articular cartilage...Read More
Evaluation of a novel technique to map the mechanical properties of an entire articular surface in indentationSim S, Quenneville E, Garon M, Hoemann CD, Hurtig M and Buschmann MDInternational Cartilage Repair Society (ICRS), Turkey, 2013, Podium presentation (11.2.9)
Purpose: Mechanical testing of articular cartilage is recommended by the FDA for products intended for the repair or replacement of knee cartilage. One experimental configuration that has many practical advantages is indentation. However, one limitation is the need to perpendicularly position the articular surface to the indenter. The objective of this study was to investigate the ability of...Read More
Ermittlung mechanischer Kennwerte mittels IndentationSeidenstucker MBioNanoMat. 2015; 16 (2-3): 152–156 DOI 10.1515/bnm-2015-9014
(In Germany only) In der Materialprüfung sind Indentationsverfahren bereits seit Jahren g?ngige Praxis. Jedoch war es bisher nicht so ohne weiteres m?glich Gewebeproben, insbesondere Weichgewebe wie Knorpel zu untersuchen. Mit dem Mikroindenter Mach-1TM von Biomomentum k?nnen sowohl flexible Biomaterialien wie Kontaktlinsen oder Wundauflagen aus elektrogesponnenen Gelatinefliesen genauso wie biologische...Read More
ASTM D5656 - Standard Test Method for Thick-Adherend Metal Lap-Shear Joints for Determination of the Stress-Strain Behavior of Adhesives in Shear by Tension LoadingASTM International, West Conshohocken, PA, 2010,
Significance and Use
This test method can be used to determine the stress-strain properties of an adhesive in shear and to establish the proportional-limit of the stress-stain relationship. This data may be useful for the design and analysis of adhesively bonded joints.
This test method is not intended to determine adhesion characteristics of an adhesive to a particular substrate;...Read More
This test method can be used to determine the stress-strain properties of an adhesive in shear and to establish the proportional-limit of the stress-stain relationship. This data may be useful for the design and analysis of adhesively bonded joints.
This test method is not intended to determine adhesion characteristics of an adhesive to a particular substrate;...Read More
ASTM D5748 - Standard Test Method for Protrusion Puncture Resistance of Stretch Wrap FilmASTM International, West Conshohocken, PA, 2012,
Significance and Use
Puncture resistance is very important in end-use performance of stretch wrap film used in consumer and industrial product applications. Puncture resistance is a measure of the energy-absorbing ability of a stretch wrap film in resisting a protrusion. The test method is designed to provide the user with a means of measuring the stretch wrap film's puncture...Read More
Puncture resistance is very important in end-use performance of stretch wrap film used in consumer and industrial product applications. Puncture resistance is a measure of the energy-absorbing ability of a stretch wrap film in resisting a protrusion. The test method is designed to provide the user with a means of measuring the stretch wrap film's puncture...Read More
ASTM D575 - Standard Test Methods for Rubber Properties in CompressionASTM International, West Conshohocken, PA, 2012,
Significance and Use
These test methods are useful in comparing stiffness of rubber materials in compression. They can be used by rubber technologists to aid in development of materials for compressive applications.
These test methods are useful in comparing stiffness of rubber materials in compression. They can be used by rubber technologists to aid in development of materials for compressive applications.
Scope
1.1 These test methods cover two test procedures for determining the compression-deflection characteristics...Read More
1.1 These test methods cover two test procedures for determining the compression-deflection characteristics...Read More
ASTM D6195 - Standard Test Methods for Loop TackASTM International, West Conshohocken, PA, 2011,
Significance and Use
These test methods provide a quantitative measure of the pressure-sensitive tack property of an adhesive.
These test methods are designed to measure the tack property of the adhesive mass. The tack of a given adhesive varies depending on the backing (generally, stiffer backings lead to higher values).
Theses test methods are suitable for quality control...Read More
These test methods provide a quantitative measure of the pressure-sensitive tack property of an adhesive.
These test methods are designed to measure the tack property of the adhesive mass. The tack of a given adhesive varies depending on the backing (generally, stiffer backings lead to higher values).
Theses test methods are suitable for quality control...Read More
ASTM D624 - Standard Test Method for Tear Strength of Conventional Vulcanized Rubber and Thermoplastic ElastomersASTM International, West Conshohocken, PA, 2012,
Significance and Use
Vulcanized rubber and thermoplastic elastomers (TPE) often fail in service due to the generation and propagation of a special type of rupture called a tear. This test method measures the resistance to tearing action.
Tear strength may be influenced to a large degree by stress-induced anisotropy (mechanical fibering), stress distribution, strain rate, and...Read More
Vulcanized rubber and thermoplastic elastomers (TPE) often fail in service due to the generation and propagation of a special type of rupture called a tear. This test method measures the resistance to tearing action.
Tear strength may be influenced to a large degree by stress-induced anisotropy (mechanical fibering), stress distribution, strain rate, and...Read More
ASTM D638 - Standard Test Method for Tensile Properties of PlasticsASTM International, West Conshohocken, PA, 2014,
Significance and Use
4.1 This test method is designed to produce tensile property data for the control and specification of plastic materials. These data are also useful for qualitative characterization and for research and development.
4.2 Some material specifications that require the use of this test method, but with some procedural modifications that take precedence when...Read More
4.1 This test method is designed to produce tensile property data for the control and specification of plastic materials. These data are also useful for qualitative characterization and for research and development.
4.2 Some material specifications that require the use of this test method, but with some procedural modifications that take precedence when...Read More
ASTM F1306 - Standard Test Method for Slow Rate Penetration Resistance of Flexible Barrier Films and LaminatesASTM International, West Conshohocken, PA, 2016,
Significance and Use
4.1 Penetration resistance is an important end-use performance of thin flexible materials where a sharp-edged product can destroy the integrity of a barrier wrap. This will permit package entry/exit of gases, odors, and unwanted contaminates, causing potential harm to the product and reducing shelf-life. Material response to penetration will vary with numerous...Read More
4.1 Penetration resistance is an important end-use performance of thin flexible materials where a sharp-edged product can destroy the integrity of a barrier wrap. This will permit package entry/exit of gases, odors, and unwanted contaminates, causing potential harm to the product and reducing shelf-life. Material response to penetration will vary with numerous...Read More
ASTM F1538 - Standard Specification for Glass and Glass Ceramic Biomaterials for ImplantationASTM International, West Conshohocken, PA, 2009,
Abstract
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More
This specification covers the material requirements and characterization techniques for glass and glass-ceramic biomaterials intended for use as bulk porous or powdered surgical implants, or as coatings on surgical devices, but not including drug delivery systems. Glass and glass-ceramic biomaterials should be evaluated thoroughly for biocompatibility before human use....Read More
ASTM F1717 - Standard Test Methods for Spinal Implant Constructs in a Vertebrectomy ModelASTM International, West Conshohocken, PA, 2015,
Significance and Use
5.1 Spinal implants are generally composed of several components which, when connected together, form a spinal implant assembly. Spinal implant assemblies are designed to provide some stability to the spine while arthrodesis takes place. These test methods outline standard materials and methods for the evaluation of different spinal implant assemblies so...Read More
5.1 Spinal implants are generally composed of several components which, when connected together, form a spinal implant assembly. Spinal implant assemblies are designed to provide some stability to the spine while arthrodesis takes place. These test methods outline standard materials and methods for the evaluation of different spinal implant assemblies so...Read More
ASTM F88-M - Standard Test Method for Seal Strength of Flexible Barrier MaterialsASTM International, West Conshohocken, PA, 2015,
Significance and Use
4.1 Seal strength is a quantitative measure for use in process validation, process control, and capability. Seal strength is not only relevant to opening force and package integrity, but to measuring the packaging processes' ability to produce consistent seals. Seal strength at some minimum level is a necessary package requirement, and at times it is...Read More
4.1 Seal strength is a quantitative measure for use in process validation, process control, and capability. Seal strength is not only relevant to opening force and package integrity, but to measuring the packaging processes' ability to produce consistent seals. Seal strength at some minimum level is a necessary package requirement, and at times it is...Read More
ASTM D2979 - Standard Test Method for Pressure-Sensitive Tack of Adhesives Using an Inverted Probe MachineASTM International, West Conshohocken, PA, 2016,
Significance and Use
This test method provides a quantitative measure of the pressure-sensitive tack of the adhesive.
The method is designed for the adhesive mass itself and is suitable for measuring the tack of pressure-sensitive adhesives for use on both rigid and flexible backings.
This test method is suitable for quality control and research purposes.
<>Read More Biomechanics and MechanoBiology of Human Cartilage ArticulationHsu FH, Alonso E, Raleigh AR, Saleh AA, Masuda K, Lotz MK, Chen AC and Sah ROrthopeadic Research Society Annual Meeting, 2016, Orlando, USA, Poster abstract 1428
Introduction: During joint articulation, cartilage, particularly that near the articular surface, undergoes a complex combination of compression, shear, and sliding.1,2 In vitro analyses have focused on cartilage biomechanics in response to relative surface movement at a constant velocity after startup. However, joint movement typically involves variability in the relative surface velocity....Read More
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