We offer radioligands and radiolabeled biomolecules to use as tracers, for radioimmunoassays (RIAs), for autoradiographic visualization, or for performing saturation and competition radioligａnd binding assays to determine receptor expression levels (Bmax), dissociation constants (Kd), association and dissociation rates (kon and koff), and inhibitor constants (Ki) for a variety of receptors. We develop our radioligands to the highest specific activity possible and provide high purity resulting in low non-specific binding products. Each of our ultra-pure radiolabeled compounds is fully characterized for pharmacological action and validated in binding assays.
Radiochemicals remain the most sensitive method for probing binding biology; yielding unprecedented sensitivity gives results that technicians and scientists can trust. For over 50 years, PerkinElmer has been a leading supplier of New Englａnd Nuclear (NEN) radiochemicals, liquid scintillation cocktails, vials and nuclear counting detection instruments.
References for NEX348:
- Gao, J.M., Xiang, R.L., Jiang, L., Li, W.H., Feng, Q.P., Guo, Z.J., Sun, Q., Zeng, Z.P., Fang, F.D. (2009), Sulfated tyrosines 27 and 29 in the N-terminus of human CXCR3 participate in binding native IP-10. Acta Pharmacol Sin., 30 (2): 193-201.
- Jenh, C.H., Cox, M.A., Hipkin, W., Lu, T., Pugliese-Sivo, C., Gonsiorek, W., Chou, C.C., Narula, S.K., Zavodny, P.J. (2001), Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor. Cytokine, 15 (3): 113-121.
規格
| 濃度 | 41.4 µCi/mL |
|---|---|
| 檢測方法 | Radiometric |
| 新鮮的很多天 | Third Monday of each month |
| 標簽位置 | Nominally Labeled |
| 產品品牌名稱 | NEN Radiolabeled Ligands |
| 放射性同位素 | I-125 |
| 放射性核素 | 125I |
| 受體類型 | Chemokine |
| 運輸條件 | 干冰 |
| 特殊訂購信息 | This is a radioactive product - shipping address must have a license to receive radioactive materials. |
| 治療領域 | Inflammation |
| 產品尺寸 | 5 µCi |
