表皮生長因子, SIGMA E4127-0.1MG

分類 抗體

級別 優級純GR

產品規格 SIGMA E4127-0.1MG

CAS 62229-50-9

品牌 Sigma

用途范圍 生物科研

保存溫度 2-8℃

英文名稱 Epidermal Growth Factor from murine submaxillary g

供應商      上海研伴實業有限公司

表皮生長因子 來源于小鼠頜下腺      品牌：SIGMA

suitable for cell culture

· 產品編號：E4127

· 中文名稱：表皮生長因子 來源于小鼠頜下腺

· 英文名稱：Epidermal Growth Factor from murine submaxillary gland

· 英文別名:EGF Epidermal cell growth factor

· CAS號：62229-50-9

· 保存溫度：2-8 °C

· EC號：263-468-7

· MDL號：MFCD01634807

訂貨信息：

產品規格價格(RMB)

· E4127-0.1MG1,838.07元

· E4127-5X0.1MG7,376.85元

注：此價格僅供參考，請以SIGMA價格為準，優惠價請電詢。

性能描述

Analysis Note

The biological activity is measured in a proliferation assay using BALB/MK cells.

Biochem/physiol Actions

Qualified for use as a mitogen for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa cells, and SV40-3T3 cells.

Preparation Note

Purified by gel filtration.

Physical form

Lyophilized from 0.2 μm filtered solution in ammonium acetate buffer.

General description

Epidermal Growth Factor (EGF) is a 6 kDa polypeptide discovered by Cohen and Levi -Montalcini and isolated from mouse submaxillary glands. EGF is mitogenic for a variety of epidermal and epithelial cells, including fibroblasts, glial cells, mammary epithelial cells, vascular and corneal endothelial cells, bovine granulosa, rabbit chondrocytes, HeLa and SV40-3T3 cells. In tissue cultures EGF can act to reduce or eliminate the requirement for serum and is often used in conjunction with other media additives and hormones, such as Insulin (Product No. I1882), Transferrin (Product No. T 5391), and Prostaglandin E1 (Product No. P7527). Cellular metabolic effects of EGF include stimulation of ion fluxes, glucose transport, glycolysis, and synthesis of DNA, RNA and proteins.

Human EGF was originally isolated from human urine as β-Urogastrone, an inhibitor of gastric acid secretion. Mouse and human EGF are 70% homologous in their sequence of 53 amino acids, act upon the same EGF receptor, elicit nearly identical biological effects and are highly inter-species cross-reactive.

EGF is structurally homologous to human Transforming Growth Factor-α (Product Nos. T7533 and T2035), which exerts its actions through EGF receptors. EGF is also homologous to a sequence contained in a 19 kDa protein of Vaccinia virus, which appears to utilize the EGF receptor to gain entry into cells. The EGF receptor is a 170 kDa glycoprotein having EGF-activated protein tyrosine kinase activity. Plaet-Derived Growth Factor(PDGF, Product No. P8147) transmodulates the EGF receptor by reduc ing both its EGF affinity and its kinase activity.

性質

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