英文名稱 MTMR14
抗體名稱 MTMR14抗體,實驗技巧肌管素相關蛋白14抗體
別    名 C3orf29; Egg derived tyrosine phosphatase homolog; FLJ11546; FLJ22405; FLJ46453; FLJ90311; HCV NS5A transactivated protein 4 splice variant A binding protein 1; HCV NS5A-transactivated protein 4 splice variant A-binding protein 1; hJumpy; jumpy; MTMR 14; MTMR14; MTMR-14; MTMRE_HUMAN; Myotubularin related protein 14; Myotubularin-related protein 14; NS5ATP4ABP1.  

濃 度 1mg/1ml 
規 格 0.1ml/0.2ml(100ug/200ug) 
公司提供的抗體達一萬多種,公司擁有Complexin I/復合素1抗體一抗,二抗,標記一抗,標記二抗等抗體種類,*價供應。
多克隆抗體制備服務：應用保證型抗體制備（ELISA,Western Blot,IHC）和修飾特異性抗體制備（磷酸化,甲基化,乙酰化）。
單克隆抗體制備服務：應用保證型抗體制備（ELISA,Western Blot,IHC）和修飾特異性抗體制備（磷酸化,甲基化,乙酰化）。
抗體純化服務：Protein A/G/L純化,抗原親和純化。
zui終抗體質檢：成品抗體或抗血清,必須通過客戶要求的所有驗證（ELISA,Western Blot,IHC等）。所有的抗原和抗體驗證數據提交客戶。
免疫組化的呈色深淺可反映抗原存在的數量，可作為定性、定位和定量的依據。
1.陽性細胞染色分布有三種類型：細胞漿、細胞核、細胞膜表面。大部分抗原見于細胞漿，可見于整個胞漿或部分胞漿
2.陽性細胞分布可分為灶型和彌漫性
3.由于細胞內含抗原量不同，所以染色強度不一。如果細胞之間染色強度相同，常提示其反應為非特異性
4.陽性細胞染色定位于單個細胞，且與陰性細胞相互交雜分布；而非特異性染色常不限于單個細胞，而是累及一片細胞。
5.切片邊緣、刀痕或褶皺區域，壞死或擠壓的細胞區，膠原結締組織等，常表現為相同的陽性染色強度，不能用于判斷陽性。
訂購:或（成）客服

MTMR14抗體,實驗技巧肌管素相關蛋白14抗體

研究領域 細胞生物  免疫學  激酶和磷酸酶  
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Rabbit, Sheep, 
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復） 
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 72kDa
細胞定位 細胞漿 細胞膜 
性    狀 Lyophilized or Liquid
濃    度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human MTMR14
亞    型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C. 

產品介紹 Myotubularin-related protein 14 (MTMR14), also known as Jumpy, is a myotubularin-related phosphoinositol-3-phosphate (PI3P) phosphatase (1). Mutations in the MTMR14 gene have been associated with centronuclear myopathy (1). MTMR14 deficiency in mice leads to altered calcium homeostasis and muscle disorders (2). MTMR14 has also been shown to play a role in autophagy, a process that is highly regulated by phosphatidylinositides through the type III PI3K, Vps34 (3). MTMR14 was localized to autophagic isolation membranes and early autophagosomes (3). In these studies, MTMR14 inhibited autophagy and mutations of MTMR14 associated with centronuclear myopathy were also defective in autophagy inhibition. In zebrafish, MTMR14 knockdown was shown to increase the number of autophagosomes, suggesting that its activity is associated with an inhibition of autophagy (4).
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