中文名稱：白細胞介素-7受體a抗體

英文名稱：Anti-IL-7Ra

產(chǎn)品編號：BYK-1540R

別名：COP9 Complex Homolog Subunit 7b; COP9 Constitutive Photomorphogenic Homolog Subunit 7b; COP9 Signalasome Subunit 7b; COP9 signalosome complex subunit 7b; COPS7B; CSN7B_HUMAN; JAB1 Containing Signalosome Subunit 7b; JAB1-containing signalosome subunit 7b; SGN7b; Signalosome subunit 7b.                                                                       

產(chǎn)品介紹：The COP9 signalosome (CSN) complex is involved in several different developmental and cellular processes. The complex is made up of several widely expressed proteins: CSN1 (COPS1), CSN2 (COPS2), CSN3 (COPS3), CSN4 (COPS4), CSN5 (COPS5), CSN6 (COP6), CSN7a (COPS7, COPS7a) or CSN7b (COP7b) and CSN8 (COP8). The CSN complex acts as a regulator for the ubiquitin conjugation pathway by mediating the deneddylation of the SCF-type E3 ligase complexes, which leads to a decrease in ubiquitin ligase activity of SCF-complexes. It is also involved in the phosphorylation of p53, c-Jun, I?Bå and IRF-8, as well as CSN-dependent phosphorylation of p53, and c-Jun protects and promotes degradation by the Ubl system. CSN7 is phosphorylated by CK2 and is composed of two subunits; a and b. CSN7a contains a PCI (Proteasome CSN9 initiation factor 3) region, as well as a coiled-coil region and is predicted to interact with CSN2, CSN3, CSN4, CSN5, CSN6, CSN8, and GPS1. CSN7b contains only a PCI region and is predicted to interact with INT6.

此產(chǎn)品本公司有標記的一抗出售，相關標記有：Alexa Fluor 350 標記、Alexa Fluor 488 標記、Alexa Fluor 555 標記、Alexa Fluor 647 標記、AP標記、APC標記、Biotin標記、Cy3標記、Cy5標記、Cy5.5標記、Cy7標記、FITC標記、Gold標記、HRP標記、PE標記、PE-Cy3標記、PE-CY5標記、PE-CY5.5標記、PE-CY7標記、RBITC標記

規(guī)格：0.1ml/0.2ml

濃度：1mg/1ml

抗體來源：本公司抗體有兔來源和鼠來源等

克隆類型：兔來源為多抗，鼠來源為單抗

產(chǎn)品類型：一抗

IL-7Ra抗體-白細胞介素-7受體a抗體保存條件：Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.

避免反復凍融，保質(zhì)期一年。

IL-7Ra抗體-白細胞介素-7受體a抗體對研究人員的多肽設計提供一些建議：

一、變難為易

1、減少序列長度

肽的長度增加導致粗產(chǎn)物純度降低，小于15個殘基的肽較容易得到.當肽鏈增加到20個以上時，正常產(chǎn)物的量就要考慮。在具體實踐中殘基低于20往往能得到更好的結果；

2、減少疏水殘基

疏水殘基占明顯優(yōu)勢的肽，尤其在距C端7―12個殘基的區(qū)域，會引起合成困難，一般認為由于合成中形成β折疊片，而產(chǎn)生不*配對。當然，可用幾個極性殘基置換，或加入Gly或Pro易打開肽結構可能會得到幫助；

3、減少“難度”殘基

有多個Cys、Met、Arg、Try殘基一般難以合成，Ser通常可作為非氧化替換。

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