產品編號 yb-1454R
英文名稱Anti-ErbB 3抗體
中文名稱 表皮生長因子受體3抗體
別 名 ErbB 3; ErbB-3; c erbB 3; c-erbB3; ERBB3; cerbB3; ERBB3 protein; cerbB; 3erbB3 S; Glial growth factor receptor; HER 3; HER3; LCCS2; MDA BF 1; MGC88033; p180 ErbB3; p45 sErbB3; p85 sErbB3; proto-oncogene-; receptor tyrosine protein kinase ERB3 [precursor]; Receptor tyrosine protein kinase erbB 3; Receptor tyrosine protein kinase erbB3; Tyrosine kinase type cell surface receptor HER3; V erb b2 avian erythroblastic leukemia viral oncogene homolog 3; v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian); v erb b2 erythroblastic leukemia viral oncogene homolog 3; ERBB3_HUMAN.
Anti-ErbB 3抗體
說 明 書 0.1ml 0.2ml
研究領域 腫瘤 免疫學 信號轉導 生長因子和激素 激酶和磷酸酶 細胞膜受體 G蛋白偶聯受體 腫瘤細胞生物標志物
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit,
產品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 147kDa
細胞定位 細胞膜 分泌型蛋白
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from the middle of human ErbB-3 (661-760aa)
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產品介紹 background:
The ErbB3 gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. ErbB3 is a membrane-bound protein which has a neuregulin binding domain but not an active kinase domain. It can therefore bind this ligand but cannot convey a signal into the cell via protein phosphorylation. However it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers including prostate, bladder and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported but they have not been thoroughly characterized.
Function:
Binds and is activated by neuregulins and NTAK.
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鈺博生物另建有七大技術服務平臺（ELISA定制服務，免疫學檢測服務、分子生物學技術服務、蛋白表達與純化技術服務、抗體制備技術服務、細胞培養技術服務、整體實驗課題服務）并代理國外試劑：abcam 抗體；MBL，eBioscience，BD，R&D,Santan,CST,RayBiotech等品牌試劑，用專業的知識、專業的設備、專業的態度為客戶提供一站式實驗技術服務！
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Anti-ErbB 3抗體 產品信息
