產(chǎn)品編號 yb-6678R
英文名稱 Anti-M Cadherin抗體
中文名稱 M鈣粘附分子抗體
別 名 M-Cadherin; Cadherin 14; Cadherin 15; Cadherin 3; Cadherin14; Cadherin15; Cadherin3; CCAD; CDH 14; CDH 15; CDH 3; CDH14; CDH15; CDH3; CDHM; MCAD; Muscle cadherin; Myotubule cadherin; CAD15_HUMAN.
Anti-M Cadherin抗體
說 明 書 0.1ml 0.2ml
研究領域 細胞生物 神經(jīng)生物學 信號轉導 細胞粘附分子 細胞表面分子 細胞膜蛋白
抗體來源 Rabbit
克隆類型 Polyclonal
交叉反應 Human, Mouse, Rat, Dog, Cow,
產(chǎn)品應用 WB=1:100-500 ELISA=1:500-1000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量 89kDa
細胞定位 細胞膜
性 狀 Lyophilized or Liquid
濃 度 1mg/1ml
免 疫 原 KLH conjugated synthetic peptide derived from human M-Cadherin
亞 型 IgG
純化方法 affinity purified by Protein A
儲 存 液 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件 Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. The lyophilized antibody is stable at room temperature for at least one month and for greater than a year when kept at -20°C. When reconstituted in sterile pH 7.4 0.01M PBS or diluent of antibody the antibody is stable for at least two weeks at 2-4 °C.
PubMed PubMed
產(chǎn)品介紹 background:
Cadherins are a family of transmembrane glycoproteins that play a key role in Calcium dependent cell-cell adhesion. Several members of the cadherin family have been identified so far, including E- (epithelial), P- (placental), N- (neuronal) and M- (muscle) cadherin. Cadherins consist of an extracellular domain containing 5 cadherin domains, a transmembrane region, and a conserved cytoplasmic domain. Transcripts from this particular cadherin are expressed in myoblasts and upregulated in myotubule-forming cells. M-Cadherin is thought to be essential for the control of morphogenetic processes, specifically myogenesis, and may provide a trigger for terminal muscle cell differentiation.
Function:
Cadherins are calcium dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
Subcellular Location:
Type 1 membrane protein.
Tissue Specificity:
Expressed in the brain and cerebellum.
DISEASE:
Note=A chromosomal aberration involving CDH15 and KIRREL3 is found in a patient with severe mental retardation and dysmorphic facial features. Translocation t(11;16)(q24.2;q24).
Defects in CDH15 are the cause of mental retardation autosomal dominant type 3 (MRD3) [MIM:612580]. Mental retardation is characterized by significantly sub-average general inlectual functioning associated with impairments in adaptative behavior and manifested during the developmental period.
Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
上海鈺博生物科技有限公司是2012年5月由“海歸”組成的創(chuàng)業(yè)團隊與兩個專業(yè)投資機構發(fā)起成立的，以開發(fā)生產(chǎn)科研試劑和特色檢驗產(chǎn)品為方向，經(jīng)過兩年多的努力，已經(jīng)建立了免疫學和分子生物學的五個技術平臺，開發(fā)了ELISA/ELISpot酶聯(lián)免疫試劑盒、重組蛋白、熒光標記抗體、四聚體（Tetramer）特異性T細胞檢測試劑盒、Aimplex流式高通量多因子檢測、microRNA 表達譜分析和功能研究等系列產(chǎn)品和服務，研究論文在Nature、Eur. J. Immunol、The Journal of Immunology和Arthritis & Rheumatism等學術期刊上發(fā)表，與國內(nèi)外免疫學、干細胞、傳染病和腫瘤研究及臨床檢驗領域的科學家們建立了良好的合作關系，形成了一定的品牌影響力。
鈺博生物另建有七大技術服務平臺（ELISA定制服務，免疫學檢測服務、分子生物學技術服務、蛋白表達與純化技術服務、抗體制備技術服務、細胞培養(yǎng)技術服務、整體實驗課題服務）并代理國外試劑：abcam 抗體；MBL，eBioscience，BD，R&D,Santan,CST,RayBiotech等品牌試劑，用專業(yè)的知識、專業(yè)的設備、專業(yè)的態(tài)度為客戶提供一站式實驗技術服務！
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Anti-M Cadherin抗體 產(chǎn)品信息
